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Effectiveness Study of Electrical Stimulation in Prevention of Decubitus.

There have been several studies that showed a possible positive effect of electrical stimulation on wound healing. One of the working principles is increasing blood flow. This could mean that by giving frequent electrical stimulation on the foot and…

Assessment of blood-brain barrier passage of flumazenil in patients with epilepsy.

Flumazenil is a substrate of P-glycoprotein at the blood-brain barrier.

Subacromial Impingement Syndrome: The Identification of etiologic Mechanisms.

Our hypothesis is, that the extrinsic mechanism in the etiology of SIS is only valid for a subgroup of patients; complaints of SIS can be caused by 1) a pathologic pattern of arm-scapula movements caused by a disrupted balance in muscle forces,…

Energy cost of walking in boys with Duchenne.

1. To determine the reproducibility and sensitivity of the Energy Cost of Walking test (ECWT) in boys with Duchenne muscular dystrophy, in comparison with the reproducibility and sensitivity of the 6-Minute Walk Test (6MWT); 2. To evaluate the 1-…

Electric stimulation of the ampullary nerves.

By sufficient electrical stimulation of the ampullary nerves, a congruent vestibulo-ocular reflex will occur.

Observational study Psychiatric Medical Unit.

(Short) stay and, if possible, treatment at the PMU, will give an improvement in regular psychometrics or at least in some of them.

Etanercept cohort studie.

Previous randomised trials have shown the efficacy of etanercept in RA patients. In this study we will evaluate the respons of etanercept in anti-TNF naive patients compared to patients who have failed other anti-TNF. We will look for clinical…

Amsterdam Wrist Rules in Children, a clinical decision aid.

Patients with a wrist trauma represent a substantial part of the patient population at the Emergency Department. Most hospitals routinely carry out a radiological examination of patients following wrist trauma to exclude a distal radius/ulna…

Verbanden tussen therapietrouw aan glatirameer acetaat (Copaxone) en ontvangen zorg bij patienten met aanvalsgewijze multipele sclerose.

Missing doses and early discontinuation are two levels of inadequate drug adherence. Multidisciplinary interventions may improve adherence. We hypothesize that in patients with multiple sclerosis (MS) certain modalities or durations of care are…

Souvenir II Open Label Extension study.

Collect long term data on compliance and safety of the study product in patients with mild Alzheimer’s disease who completed the Souvenir II study.

Prostate Cancer Molecular Medicine (PCMM).

Current methods of detecting the presence and/or prognosis of prostate cancer are not optimal. New markers will provide better detection and/or better methods to determine prognosis. In addition, there are currently no methods available to properly…

Imaging the brain of children with obesity.

We hypothesize that early programming leads to differential brain function. A result of these changes in brain function will be differences in energy expenditure and food intake leading to different eating behaviour and differences in sensitivity to…

The prodromal phase of Parkinson's Disease; Symptoms, duration, health care resource use and costs over a 5-year period prior to the diagnosis is made.

De vroege beginfase van de ziekte van Parkinson; Symptomen, duur, zorgconsumptie en gezondheidszorgkosten in de 5 jaar voorafgaande aan het stellen van de diagnose.

Idiopathic Parkinson's Disease is a chronic progressive neurodegenerative disorder. The preclinical phase of the disease is accompanied by different motor and non-motor symptoms and signs. These symptoms can occur even 5-8 years before…

Rhinovirus type 16-induced exacerbation in asthma.

We hypothesize that the ASM phenotype of asthmatic patients: 1. Changes during an experimental, rhinovirus type 16 (RV16)-induced exacerbation; 2. Is associated with enhanced airway inflammation and hyperresponsiveness during an experimental, RV16-…

Delta Xtend reversed shoulder prosthesis.

Our primary objective is to compare the short-term (one-year follow-up) clinical results of the DePuy Delta Xtend reversed shoulder prosthesis with conservative treatment, in the management of displaced four-part fractures of the proximal humerus of…

Nutrition surveys in Southeast Asia.

To assess the nutritional status and dietary habits of children aged 0.5-12 years in Indonesia, Malaysia, Thailand and Vietnam.

Een fase I/II vaccinatie studie met patient eigen dendritische cellen geladen met TAT, REV en NEF mRNA in HIV geïnfecteerden tijdens stabiele HAART.

This study is designed to determine safety and toxicity of the administration of autologous DC electroporated with mRNA encoding the early expressed HIV-1 proteins Tat, Rev and Nef in patients who are virologically and immunologically responding to…

The relationship between the conversion and excretion of docetaxel and paclitaxel and variation in DNA.

The inter-individual pharmacokinetic and pharmacodynamic variability for the anticancer drugs docetaxel and paclitaxel is due to patient characteristics, genetic variability and life style factors.

Diabetes and sexuality: An evaluation of the need for care among diabetes type 2 patients.

Diabetes en seksualiteit: Een inventarisatie van de zorgbehoefte bij type 2 diabetespatienten.

Diabetes patients have an elevated risk to develop sexual dysfunctions. These sexual problems can have a negative impact on the quality of life of these patients. Despite this negative influence, little attention seems to be paid to these sexual…

Gemcitabine en radiotherapie in combinatie met panitumumab bij patiënten met niet uitgezaaide, inoperabele alvleesklierkanker.

The addition of panitumumab to radiotherapy plus gemcitabine will increase the number of patients who are alive and progression free at 7 months.