254 results
The aim of the study is to test the hypothesis that susceptibility to and severity of certain infectious and inflammatory diseases can be explained by the interaction between the genome, microbiome and immunological responses: i.e. presence of…
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
To study prevalence and consequences of cognitive, psychological, social and functional decline in elderly breast cancer patients, in comparison to a population elderly without breast cancer.
The aim of this study is to determine whether the presence and the extent of periodontitis are independently related to the presence and extent of coronary calcification.To determine if periodontal treatment has an positive effect on the…
Primary:- To measure the effect of Teriflunomide on lymphocytes subsets in patients with relapsing forms of multiple sclerosis as compared with baseline values and those of a reference population of untreated healthy subjects.Secondary:- To assess…
The primary objective of this study is to investigate the effect of food on the pharmacokinetics(PK) of olaparib following oral dosing of the tablet formulation in patients with advancedsolid tumours.The secondary objectives are to investigate the…
The primary objective of the present study is to demonstrate that maintaining sinus rhythm after ECV for persistent AF in patients with severe chronic heart failure and reduced ejection fraction reduces NT-proBNP levels.
1. To explore the validity and usefulness of Bone Microindentation Technique (BMT) in the assessment of bone quality in patients with osteoporosis and a spectre of bone diseases characterised with (localised) increased bone turnover. 2. To study the…
The primary objective of the study is to assess the safety and tolerability of long-term open-label CP-690,550 therapy in subjects with CD.Secondary objectives are to evaluate the effect of CP-690,550 maintenance therapy on clinical remission and on…
In the current study, we want to demonstrate Rienso uptake in the vessel wall in patients with cardiovascular disease and relate the uptake of Rienso to endothelial permeability.
The primary objective of the proposed study is to examine the neural substrate of cognitive and social-emotional apathy in patients with schizophrenia. Secondary, we intend to explore the concentration of brain metabolites and structural differences…
-To determine the feasibility of detection of synovitis by photoacoustic imaging using three discrete wavelengths of pulsed light as an early indicator of the presence of RA.-To correlate the photoacoustic markers that are indicative for…
The overall objective of this study is to examine specific cardio-metabolic and cardiovascular parameters in women of subfertile couples. This study protocol is divided in 3 studies to evaluate several cardio-metabolic/cardiovascular parameters in…
The project has three main scientific objectives: (1) To investigate how speech processing with CIs affects listeners* mental representations at lexical and sub-lexical levels, as well as the flow of information between these levels; (2) To study…
To map phenomenolocal characteristics of hallucinations and delusions in psychiatric and neurologic patient populations as well as in the general population. By comparing this between all groups, different subtypes of hallucinations and delusions…
The current study aims to investigate the effect of a) caloric restriction (very low calorie diet (VLCD)); b) caloric restriction with mechanical restriction and physiological changes through malapsorption (Roux- en- Y bypass (RYGB) surgery); and c…
Primary objective of this study is to assess the reliability and validity of the neuromuscular parameters of ankle joint impedance estimated by nonlinear SIPE technology in children with CP compared to current clinical manual tests and gait analysis…
The frontotemporal syndrome in amyotrophic lateral sclerosis: screen, impact, imaging and pathology.
The main objectives are: 1. to develop a diagnostic tool for the assessment of the frontotemporal syndrome. 2. To investigate the structural and functional brain networks of ALS patients with and without a frontotemporal syndrome, in order to gain…
The objective of the study is to investigate the applicability of the whole body MRI protocol in Gaucher disease. To do so, we will investigate:1. If whole-body MRI ironmeasurements represent the distribution and total amoount of Gauchercells in the…
To assess the number of patients in remission, 12 months after dose adjustment of IFX from 5mg/kg to 3 mg/kg. Secondary objectives include: number of relapses, defined by increase of fecal calprotectin and/or CRP and clinical activity, subsequently…