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Non-invasive assessment of skeletal muscle involvement in Duchenne muscular dystrophy

To develop non-invasive markers for tissue changes in skeletal muscle using MR methods

Immune response after Human Papillomavirus vaccination in patients with automimmune disease

Objective: The primary goal of the current study is to study the immunogenicity and safety of HPV vaccination in patients with an autoimmune disease. Based on retrospective analysis with other vaccines we hypothesize that patients with autoimmune…

Pharmacogenetics of Asthma Medication in Children: Medication with Anti-inflammatory effects with special focus on Neutrophils.

The overall aim of the project is to define effects of genetic and non-genetic variants on pharmacological treatment response in children with asthma. The following questions will be answered:- What are the characteristics of children who do not…

Complications of PCOS Pregnancy: Evaluating Risk

To design a multivariate prediction model of pregnancy outcome in women with PCOS with the intention to define intervention strategies for the future.

Early detection of carcinoma in situ of the testis with a new non-invasive method.

The aim of this research is developing a non-invasive a method of early detection of CIS using scrotal ultrasound and semen diagnostic on CIS-cells. The results of this research will be used for the set-up of a screening study of CIS at men with an…

A Multicenter, Prospective, Long-term Registry of Pediatric
Patients with Crohn*s Disease and Ulcerative Colitis

The objective of this registry is to obtain long-term safety and clinical statusinformation on pediatric patients with IBD (ie, CD, UC, or IC).

Imaging in amyotrophic lateral sclerosis;
novel biomarker research with 7Tesla MRI

Identify and further explore the structural brain alterations in ALS patients in comparison to healthy controls and to investigate the correlations of anatomical changes with clinical variables.

Unravelling the aetiology of pyloric stenosis; a role for the COL3A1 gene?

The aim of this study is to improve insight in potentially genetic factors contributing to the development of pyloric stenosis.We aim to investigate the association of the COL3A1 gene and pyloric stenosis because of concrete signs in the existing…

Spatiotemporal properties of the flexion/extension movements of the cervical spine in patients with a chronic whiplash associated disorder and healthy controls

This study aims to investigate differences in spatiotemporal properties of the active movements in of the cervical spine in the sagittal plane in chronic WAD patients and healthy controls.

Impulsivity, empathy and paranoia and the role of gene-environmentinteractions in the aggressive-delinquent phenotype

This research proposal focuses on (i) the development and implementation of experimental approaches to identify dimensions of impulsivity, empathy and paranoia. (ii) Studying the gene-environmentinteractions which are expected to play a role in the…

Effect of aroma quality on ad libitum food intake at different viscosities

Primary Objective: Investigation of the effect of the quality of aroma on ad libitum food consumption, taking into account the multimodal integration between aroma and viscosity.Secondary Objective(s): Investigation of the effect of viscosity on ad…

Coronary artery calcification measured with multi detector-row computed tomography in patients with hemophilia A

To investigate whether patients with hemophilia A develop less coronary artery atherosclerosis as compared to non-hemophilic males.

The Ganesh Study. Risk factors for diabetes and cardiovascular disease in Surinamese South Asian children aged 5 through 12 years and the relation to anthropometry.

Aim of this study is to acquire more insight in the relation between risk factors for cardiovascular disease and type 2 diabetes and anthropometric measures such as BMI, waist circumference and body fat percentage and compare the results between the…

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 in Subjects With Postherpetic Neuralgia and Post-Traumatic Neuralgia, Followed by a Double Blind Safety Extension and an Open-Label Safety Extension

Primary Objectives• To evaluate the analgesic efficacy of JNJ-42160443 (1, 3, and 10 mg; administered as a single, subcutaneous injection every 28 days) in reducing average pain intensity, in subjects with postherpetic neuralgia neuralgia • To…

Pathogenesis of community-acquired pneumonia, chronic obstructive pulmonary disease and cystic fibrosis: mechanism of inflammatory response and the role of Th17 differentiation

To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis

Cardiac sympathetic innervation and coronary blood flow regulation during general anesthesia

1. Does general anesthesia affect autonomic sympathetic control of coronary blood flow in healthy subjects?2. Does acute inhibition of autonomic sympathetic innervation by means of a thoracic epidural or a thoracic sympathectomy additionally impair…

New influenza A (H1N1) disease incidence and immunogenicity of the pandemic influenza A(H1N1) vaccine in healthy adults

Primary: Evaluate new influenza A (H1N1) disease (pandemic influenza) incidence of vaccinated compared to unvaccinated individuals. Secondary: * Obtain data on immunogenicity of pandemic influenza vaccination:- Evaluation of the humoral immune…

Aberrant endothelial and smooth muscle progenitor cell frequency and function in Type 2 diabetes: a predisposing factor for increased cardiovascular risk?

1) Determine differences in EPC and SMPC availability in the peripheral blood of T2DM patients with or without coronary artery disease (CAD) or peripheral artery disease (PAD) as well as in age- and sex-matched non-diabetic subjects with or without…

Sleep State Misperception Mispercieved?

We aim to establish whether our judgment of *misperception* is really doing justice to the condition paradoxical insomniacs suffer from. We should keep in mind that our present definition of sleep, based on the standardized polysomnographic scoring…

Thiazolidinedione Intervention with Vitamin D Evaluation (TIDE). A Multicenter Randomized Double-Blind Placebo-Controlled Trial of a Thiazolidinedione (TZD) or Placebo and of Vitamin D or Placebo In People With Type 2 Diabetes at Risk For Cardiovascular Disease.

This trial will determine the relative incidence of CV outcomes compared to placebo forthe TZD class as a whole, rosiglitazone (RSG), and pioglitazone (PIO) when added to thetherapeutic regimen of a person with type 2 diabetes who has additional…