27 results
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
The aim of this study is primarily to investigate the effects of a withdrawal intervention on measures of driving performance in a clinical population that uses benzodiazepines, Z-hypnotics, or opioid analgesics chronically. As a secondary objective…
The primary objective is to measure the real-world daily activity in a representative cohort of 1100 longterm survivors after Ewing tumor treatment using portable devices, and to describe the functional outcome and health-related quality of life…
What is the correlation between change in % fall in FEV1 (*FEV1) after an exercise challenge 20h after a single dose of montelukast and after 4 weeks of treatment with montelukast?
Primary Objective: comparing hemodynamic stability provided by titration of esmolol in addition to standard perioperative care including low-dose metoprolol to placebo and standard care.Secondary Objective(s): -comparing the incidence of…
The purpose of this study is to document the efficacy, measured by allogeneic blood transfusion rate, of the Sangvia® Blood Management System when used for intra-operative, and if bleeding continues after surgery, possibly also postoperative…
Primary:To determine trends in vaccine- and nonvaccine-serotype S. pneumoniae asymptomatic colonisation in healthy 11-month-old and 24-month-old infants who have been immunized according to the Dutch NIP with 7-valent pneumococcal conjugate vaccine…
The purpose of this study is to evaluate whether thyroid hormone replacement therapy in type 2 diabetic patients suffering from overt hypothyroidism will improve muscular mitochondrial function, lower ectopic fat accumulation in muscle and liver,…
- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) prevent deterioration of the bladder and renal function?- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) decrease the need for an…
The purpose of the study is to test whether a centre-wide policy of incremental antibiotic therapy will reduce arrhythmia device infection in patients undergoing arrhythmia device procedures compared to a policy of conventional antibiotic…
How long does B-cell memory persist after a single conjugate MenC vaccination and which cells are involved? How is this related to the age of first vaccination? And how to define correlates of protection for immunity and memory after MenC conjugate…
The goal of the study is to find out whether micturition complaints are prevented or reducted by the bladder instillations with Uracyst and secondly if it has a positive effect on painscores and micturition related quality of life.
What is the correlation between change in Mannitol PD15 (provoking dose of mannitol to cause a >= 15% fall in FEV1 ) 6h after a single dose of beclomethasone and after 4 weeks of treatment with beclomethasone?
To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…
Primary objective:To investigate Pertussis Toxin (PT) specific antibody responses 1 month following the second aP vaccine given at 5 months of age to infants whose mothers have (Arm 1) or have not (Arm 2) received a pertussis booster vaccine during…
The main objective of this study is to determine differences in vaccine responses in the pre-elderly age group (50-65 years of age) to a primary immunization with vaccine antigens to which no or (very) low pre-vaccination antibody levels and memory…
Primary objective: to determine the vaccine efficacy of PCV13 plus PPV23 (2-month series) in cases, i.e. IBD patients treated with immunosuppressive agents, vs controls. Secondary objectives: - To assess if the use of a TNF-alpha inhibitor affects…
To determine the impact of prior BCG vaccination on the duration of immunogenicity of the BioNTech/Pfizer mRNA COVID*19 vaccine.
1) to investigate if patients on chronic NOAC treatment are sufficiently anticoagulated without additional UFH during CAG/PCI, and 2) if this sufficient anticoagulation can be confirmed pre-procedure by a point-of-care test, and3) to investigate if…
The primary objective is to investigate the effect of an anti-inflammatory diet on HRQoL and pain symptoms in women with endometriosis. The secondary objective is to investigate the effect of an anti-inflammatory diet on inflammatory characteristics…