53 results
The primary objective is to determine the safety and tolerability BCG vaccination followed by controlled human malaria infection; and to determine the protective efficacy BCG vaccination against a controlled human malaria infection.
The first objective of this study is to gain insight in which neurocognitive and neurobiological processes underlie the development of externalizing behavior (in specific aggressive behavior) in the first two years of life. The second objective is…
Primary objective: To prospectively evaluate the lesion (AN-)count, i.e. abscesses, inflammatory nodules, and draining sinuses, in the axilla treated with MWA compared to the untreated contralateral axilla after six months.Secondary objectives: - To…
Primary Objective: Can catheter directed thrombolytic therapy, for the treatment of primary IFDVT, safely and effectively reduce post thrombotic morbidity after one year?Secondary Objective: Does catheter directed thrombolytic intervention have a…
1. What is the effect of a photo series of unaltered vulvas on genital self image in women who consider a labial reduction.2. Does the diagnosis BDD; the reason to consider a labial reduction (aesthetic or functional); sexual functioning; sexual…
Primary Objective:To assess the difference in healing complications up to and 21 days post-operatively between postsurgical incisions treated with PICO compared with standard of care Incision healing complications will include;* Skin necrosis*…
1. Is KJD clinically non-inferior to current surgical techniques (HTO and TKP)?2. Is KJD superior to HTO in actual structural repair of cartilage?3. Is KJD cost-effective in the long-term compared to HTO and TKP?
The current randomized study aims to evaluate potential differences between the Edwards SAPIEN bioprosthesis and the Medtronic CoreValve® system with main focus on periprosthetic aortic regurgitation and additional focus on other clinical and…
The objective of the study is to investigate the glucose lowering potential and safety of continuation of Metformin during non-cardiac surgery, compared to discontinuation of Metformin 24 hours before surgery.
In this study, the following questions will be answered:1. Does larval therapy accelerate wound healing?2. Do single larval secretions accelerate wound healing?3. Is the bacterial load in the wound reduced during larval therapy or is the microbiome…
To determine the effects of renal sympathetic denervation on insulin resistance and muscle sympathetic nerve activity (MSNA) in patients with metabolic syndrome at 3 months after renal denervation.
The aim of this study is to compare the effect of a postoperativenegative pressure dressing (Prevena (TM) IMS) with a standardwound dressing (care as usual) in clean closed surgical wounds on the prevention of wounddehiscence in low riks and high…
The primary objectives of the present study are to compare the effect of pretreatment with two different fractional laser modalities (CO2 and Er:YAG laser) on topical anesthesia and to compare the anesthetic effect of two different topical…
The overall objective is to assess the effectiveness of treating patients with corticosteroids prior to surveillance in order to diminish the pitfall of active inflammation.
1. To evaluate whether patients with FCH have different pattern of hypothalamic neural activity compared to healthy control subjects, 2. To evaluate whether patients with FCH (index patients) have a different pattern of hypothalamic neural activity…
The main research question of this study is: 1. Does CBITlead to a reduction of fatigue severity in adult patients with CFS compared to a waiting list condition? Secondary research questions for phase one of the study: 2. Does CBIT lead to a…
The purpose of the study is to investigate the safety and effectiveness of the HF IF PIOL, and to compare performance with the Artiflex lens. Study outcomes will be used to obtain CE marking for the lens and for registration and marketing purposes.
The primary objective of this study is to assess the analgesic effect of fractional carbon dioxide laser assisted delivery of two topical anesthetics (articaine hydrochloride 40 mg/ml and epinephrine 10 µg/ml solution (AHES) and eutectic mixture of…
The objective of this trial is to investigate whether adding acute APT to rt-PA thrombolysis in ischemic stroke reduces death or dependency at 3 months.
Primary objectiveTo assess the efficacy of intravitreally (ITV) administered VEGF Trap-Eye compared to ranibizumab (in a non-inferiority paradigm) in preventing moderate vision loss in subjects with all subtypes of neovascular AMD Secondary…