268 results
The primary objective of this investigator initiated project is to determine whether the use of the WalkinSense in the production of new fully customized therapeutic footwear for diabetic patients with a history of foot ulceration results in lower…
To investigate whether an interactive internet-based intervention strategy targeting vascular and lifestyle-related risk factors can lead to improvement of cardiovascular risk profile and prevention of cardiovascular disease and whether this in turn…
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
To assess swallowing and speech function in patients ten years after CRT for head and neck cancer with preventive rehabilitation in order to compare these results with those after six years and to those of patients after CRT without preventive…
The aims of this project are to:1. Assess what percentage of breast cancer patients experience accelerated gain in fat mass, loss of muscle mass and muscle strength as induced during chemotherapy2. Assess whether changes in energy intake, protein…
The current study aims to investigate the effect of a) caloric restriction (very low calorie diet (VLCD)); b) caloric restriction with mechanical restriction and physiological changes through malapsorption (Roux- en- Y bypass (RYGB) surgery); and c…
The objective of this study is to investigate the user satisfaction, use, effectiveness and economic outcomes of the PERSSILAA platform for older adults suffering from functional decline in the physical and/or cognitive domain and/or suffering from…
The Lipid-rich Plaque Study will be performed in patients undergoing IVUS-NIRS imaging (the index procedure) in whom a TVC catheter will be purchased and used for routine clinical indications. The study will test the ability of multi-vessel NIRS…
2.1 Primary objectives2.1.1 Cross-sectional part• Technical evaluation of the functional and structural outcome measures to support a biomarker qualification by regulatory authorities and payers. 2.1.2 Longitudinal part • Assessment of prognostic…
The aim of this study is primarily to investigate the effects of a withdrawal intervention on measures of driving performance in a clinical population that uses benzodiazepines, Z-hypnotics, or opioid analgesics chronically. As a secondary objective…
The main objective of this study is to evaluate whether our protocol results in non-functional overreaching in athletes in a controlled and safe way
We aim to gain insights in proximal and distal tubular reabsorption of iron, transferrin, NTBI and labile plasma iron (LPI). To this purpose, we will study urinary iron, transferrin, NTBI and LPI concentrations relative to urinary creatinine…
The aim of Prevent CardioKids is to evaluate to what extend disturbed vascular function markers are present in children of different weight categories and whether these are age dependent. Also differences * and relationships between * vascular…
To study the effectiveness of the PhysioDom HDIM intervention in maintaining or improving nutritional status and quality of life. Furthermore, the effects on behavioural determinants, appetite, dietary intake, weight, physical activity, and physical…
Primary Objective: To prospectively assess the impact and relevance of several risk factors for SAA/acute wheeze that have been identified in retrospective studies, including our own. Secondary Objective: To assess short-term medical and…
Main objective: To investigate whether spironolactone can favourably alter extra-cellular matrix remodelling, assessed by changes in the fibrosis biomarker Procollagen Type III N-Terminal Peptide (PIIINP), in patients at increased risk of developing…
The aim of this study is to investigate the effect of guided tapering in early pregnancy as compared to continuation of SSRIs during pregnancy. We will study effects on both mother and child with a pragmatic approach.
The aim of the study is three-fold: First to reveal the clinical course of overweight, second to reveal the clinical course of complaints in overweight and non-overweight children and third to identify leads for prevention of (sustained) overweight…
Main objective This research focuses on the outcomes of domestic violence at various levels in the family system, where we consider the severity of domestic violence as a determining factor. The relationships in the model are tested in families…
To find out if there is a protective effect of postconditioning on ischemia reperfusion-injury in kidneytransplantation.