54 results
Systematic gathering of biomaterial and phenotypic data of IBD patients during clinical care provides assessment of molecular markers in the DNA, the transcriptome and proteome. The markers can be associated with the different disease phenotypes…
This research aims to determine factors involved in subfertility and serious pregnancy complications that arise early in pregnancy. Due to increased insight into the pathogenesis of these conditions, primary prevention should ultimately be possible.
Investigate the effect of having CYP2C19 and CYP2D6 genotypes at start of antidepressant therapy and it’s cost-effectiveness in the primary care setting.
Subgroup 1 (complex appendicitis without mass and/or abscess formation): LA is associated with reduced superficial site infections, shorter length of stay, less costs, less pain, and better hr-QoL, compared with OA without compromising overall…
To determine the content validity and clinical utility of the Dutch sPCI according to nurses with expertise in stroke care and stroke patients, respectively.
To establish the diagnostisch accuracy of ultrasound for the exclusion of fracture of the elbow
The primary aim of this split-mouth randomized clinical trial is to assess accuracy of bracket positioning of a fully digital IDB workflow compared to a DBB workflow, with IDB bracket planning serving as reference for both methods. The secondary…
Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals
Objective The objective of this study is to assess which risk scoring model is most cost-effective for the discrimination between benign and malignant ovarian tumors that guides referral decisions for women with ovarian tumors in the Netherlands…
The study will address the feasibility of the shared decision-making (SDM) intervention by (1) analysing the acceptability of the intervention by users (i.e. professionals and patients); (2) assessing the level of implementation; (3) testing…
To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…
NA
We hypothesize (based on literature) that the incidence of chronic pain in The Netherlands is around 15-20% in patients presenting to the emergency department with (acute) pain related complaints. We have no further hypothesis, because of the…
to compare the short-term toxicity of the conventional schedule of 25 x 2 Gy, once daily fractionation in a five-week Overall Treatment Time (OTT) to 14 x 3 Gy, once daily fractionation in a three-week OTT, with respect to the rate of postoperative…
The purpose of this study is to generate clinical evidence related to key performance outcomes of Endurant II/IIs Stent Graft System versus Gore Excluder/Excluder Conformable AAA Endoprosthesis in subjects with AAA.
Evaluation of the effect of different treatment thresholds in a clinical pathway for children with acute asthma who are treated with supplemental oxygen
To evaluate the (cost-)effectiveness of SBRT (with active dose-sparing of the surgical site) followed by surgical stabilization with or without decompression within 24 hours for the treatment of symptomatic, unstable metastases of the cervical,…
We will combine four 7 Tesla MRI markers in extremely preterm infants (MRSI; SWI; PC-MRI; ihMT) to assess (1) if they can predict outcome until 2 years of age; (2) if they are of added value to 3 Tesla prematurity (Kidokoro et al., 2013) and (3) if…
The LIMONCELLO study aims to assess the effect and cost-effectiveness of TMPC compared to usual care.
We want to compare the effectiveness of sclerotherapy and rubberband ligation when it comes to symptoms. We will secondarily consider patient satisfaction, complications and recurrences. We hypothesize that both treatments are equally effective.