41 results
Answering the question if there are any associations between hormonal status in adolescence on the one hand, and immunological reactivity and pharmacodynamics on the other hand; and if such associations can explain the more rapid deterioration of…
The aim of this trial is to study if physical performance improves and protein energy wasting decreases in patients who change from conventional hemodialysis to nocturnal hemodialysis, compared to patients who continue their treatment on…
We aim to gain insights in proximal and distal tubular reabsorption of iron, transferrin, NTBI and labile plasma iron (LPI). To this purpose, we will study urinary iron, transferrin, NTBI and LPI concentrations relative to urinary creatinine…
First, to determine the extent to which microcirculatory perfusion defects occur during clinical kidney transplantation. Second, to study the relationship between these events and kidney function, inflammation and renal cellular injury. Third, to…
The aim of the study is to investigate the changes in peritoneal endothelial glycocalyx in end-stage renal disease (ESRD), with the duration of peritoneal dialysis, and relate these changes to alterations in peritoneal transport and morphology.…
The aims of the present study are 1) to confirm the high prevalence of dRTA in Sjögren using the urinary acidification test with ammonium chloride, 2) to determine the prevalence of disorders in calcium metabolism in pSS patients with dRTA, 3) to…
To elucidate the molecular mechanisms underlying renal disease that lead to chronic kidney disease. To validate pathogenic variations in functional in vivo models.
The main objective is to study the effect of renal transplantation with a living donor on selected cardiovascular, nutritional and activity parameters in both recipients as well as living donors.
The objective of this study is to investigate the role of inflammatory mediators (circulating platelet activity levels, MP numbers, and levels of plasma/urinary mtDNA) to the occurrence and severity of acute rejection and renal outcome.
To measure changes in urinary RAS components during an acid-loading test in patients with CKD and healthy controls.
The study has 3 objectives: 1. Proving that this form of RCA does not increase the risk of bleeding while achieving a degree of anticoagulation of the extracorporeal system that is similar to that when using LMWH. When this study shows that citrate…
The current study is designed to test the hypothesis that the medulla in transplanted kidneys is still hypoxic at 1 day after transplantation using a non-invasive method: BOLD MRI.By studying two groups a comparison can be made between patients…
To investigate the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related target-organ damage (renal insufficiency and heart failure).
To determine the general usefulness of and a proper moment when blood should be taken for the in vitro IFN-γ assays in patients undergoing chronic haemodialysis.
To assess the impact of 7 daily subcutaneous gifts of GH on circulating Klotho levels in human sugjects with CKD stage III and healthy age-matched controls.
The objectives of this study are to determine the prevalence of dRTA, osteoporosis and nephrolithiasis in patients with SS. We also try to elucidate the mechanism which is responsible for developing dRTA in patients with SS. The role of auto…
The main of objectives are to study the effect of the start of dialysis treatment (hemodialysis and peritoneal transplantation), on selected cardiovascular, nutritional parameters as well as physical activity. Secondly, a differentiation will be…
First, to determine the extent to which oxidative stress and microcirculatory perfusion defects occur during clinical kidney transplantation. Second, to study the relationship between these events and kidney function, inflammation and renal cellular…
The major aim of this project is to elucidate the molecular basis of IgAN. A large cohort of IgAN patients will be screened on aberrancies in the DNA sequence or expression of the gene encoding Cosmc, a protein that is essential for the biosynthesis…
Primary objective of the study is•To investigate the change of Urinary Albumin-to-Creatinine ratio (UCAR) after 90 days treatment Secondary objectives of the study are•To assess safety and tolerability of these doses by assessing the effects on…