21 results
To compare the protein profile of Barrett*s mucosa with and without early neoplasia in ER specimens in epithelial and stroma aiming to identify a biomarker indicating presence of early neoplasia in BE.
To obtain fluid from the the gastric acid pocket to:1.) Compare fluid of patients on ppi, patients with Barrett's esophagus and volunteers2.) to assess the properties of the fluid to develop a reliable in vitro model
Purpose:We like to determine the movement of the intestinal contents to measure the peristaltic movement/ motility.
To study potential abnormal functioning of the bile salt-FXR-FGF19 axis in patients with clinically quiescent Crohn*s colitis.
To evaluate the bowel function, quality of life and nutritional status in adolescents/adults who experienced an episode of NEC at neonatal age.
To investigate the effect of capsaicin infusion on mucosal integrity. We will evaluate mucosal impedance and the histology of the esophageal mucosa. In addition, we also aim to assess the involvement of the TRPV1 receptor by evaluating the possible…
To study potential abnormal functioning of the bile salt-FXR-FGF19 axis in patients with clinically quiescent Crohn*s colitis.
Systematic gathering of biomaterial and phenotypic data of IBD patients during clinical care provides assessment of molecular markers in the DNA, the transcriptome and proteome. The markers can be associated with the different disease phenotypes…
This study aims to gain insight into the effect of inflammatory factors on bone metabolism. For this purpose we formulated the following research questions:1. Which circulating inflammatory factors play a central role in the pathogenesis of general…
1. To determine the prevalence of gastric fundic gland polyps in patients undergoing routine upper gastrointestinal endoscopy2. To determine the prevalence of dysplasia in these gastric fundic gland polyps3. To determine the prevalence of gastritis…
What is the prevalence of depression and anxiety in children with asthma. Is this more frequent in asthma than in other chronic conditions like diabetes and Coelikie? And how compares this to healthy children in the same phase of life?
The present study aims to extent the sparse knowledge on sexual function in IBD by 1) examining the prevalence of sexual problems in men and women with IBD (including Crohn*s disease and ulcerative colitis), 2) comparing this with the prevalence of…
This research aims to assess the effect ofn completing an ACA-task on decision-making regarding short-course pre-operative radiotherapy in the treatment of rectal cancer in clinical practice.
To investigate different types of biomarkers in blood from patients with a HPB malignancy, HPB related disease as well as from healthy volunteers in order to identify biomarkers that serve as early predictors for the development of HPB malignancies…
1. Primary objective: 1.2 To assess the correlation of protein profiles between intestinal tissue and serum in patients with IBD2. Secondary Objectives:2.1 To identify the source matrix that has the highest chance to yield clinically relevant IBD…
With this study, we aim to gain insight in the influence of dietary oxalate on urinary oxalate levels by quantification of the intestinal oxalate absorption in patients with recurrent idiopathic calcium oxalate stones, primary hyperoxaluria, and…
To determine the long-term outcome after necrotizing enterocolitis during neonatal life, regarding (pain) sensitivity, sensory processing, behaviour, executive function, scar satisfaction (in surgically treated NEC patients), and (health-related)…
To investigate the effect of oral curcumin supplementation on different clinical parameters and the gut microbiota composition in patients with diabetes type II, inflammatory bowel disorders (both ulcerative colitis and Crohn*s disease in remission…
The primary objective of the present study is to assess the involvement of the duodenal TRPV-1 neuropeptide pathway in symptom perception in FD patients compared to healthy controls. The present study has several secondary objectives with regard to…
To validate promising circulating predictive biomarkers for FOLFIRINOX response in patients with PDAC, found in our previous pilot cohort (iKnowIT study, NL65025.078.18, MEC-2018-087) and to generate a biobank of blood samples to investigate future…