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Treatment of port wine stains using Pulsed Dye Laser, Erbium Yag Laser and topical sirolimus in an open label pilot study (POLAR).

Primary: to evaluate and compare the efficacy of:1) PDL treatment followed by topical sirolimus application after Er:Yag laser ablation of the stratum corneum in PWS 2) PDL treatment followed by topical sirolimus application without Er:Yag laser…

A pilot study to investigate whether fatigue is a side effect of etanercept in patients with moderate to severe psoriasis

To investigate whether fatigue is a side effect of etanercept.

Optimising adalimumab treatment in psoriasis with concomitant methotrexate.

Primary: *To assess if combination therapy of adalimumab and MTX significantly improves the drug survival at one year compared to adalimumab monotherapy in patients with moderate-to-severe psoriasis.Secondary: *To assess if combination therapy of…

Short term clinical efficacy of topical treatment with clindamycin-benzoyl peroxide gel compared with clindamycin lotion in mild to moderate Hidradenitis Suppurativa

Therefore the primary objective of this study is to evaluate the effect of twice daily application of topical clindamycin1%/benzoyl peroxide 5% gel compared with the standard treatment with topical clindamycin1% lotion on the frequency of active…

A Phase 3b/4 Randomized, Open-label, Efficacy Assessor Blinded Study, Comparing the Safety and Assessor Blinded Efficacy of Upadacitinib to Dupilumab in Subjects with Moderate to Severe Atopic Dermatitis (Level-Up)

This study compares upadacitinib to dupilumab in adolescent and adult participants with moderate to severe AD who have inadequate response to systemic therapies. Adverse events and change in the disease activity will be assessed.

Intralesional bleomycin treatment of keloids using an electronic pneumatic jet injector: a double-blind randomized, placebo-controlled trial with split-lesion design

Primary objective: To explore the effect on volume of keloid tissue (mm3), measured by 3D-camera, after three consecutive treatments with electronic jet injector assisted bleomycin delivery, compared with placebo in a split-lesion design.Secondary…

A two-part (observational and intervention) study to explore disease characteristics of vulvar (pre)malignancies compared to healthy volunteers.

Primary Objectives- To evaluate disease related characteristics in patients with different vulvar conditions compared to healthy volunteers - To evaluate the variability of the selected biomarkers between subjects, and within subjects over time.…