Search for a trial

Nijmegen Exercise Study: the role of physical activity on the prevention of cardiovascular diseases

The primary purpose of this study is to determine the relation between a physically active lifestyle and the primary and secondary prevention of diseases and death.Using an online questionnaire, we will approach all civilian participants of the…

Fifteen years of statin therapy started in childhood: efficacy, safety, compliance and tolerability in patients with familial hypercholesterolemia

The aim of this study is to evaluate the efficacy, safety, compliance and tolerability of 15 years of pravastatin therapy initiated during childhood in young adult FH patients.

Perioperative esmolol infusion for haemodynamic stability during major vascular surgery.

Primary Objective: comparing hemodynamic stability provided by titration of esmolol in addition to standard perioperative care including low-dose metoprolol to placebo and standard care.Secondary Objective(s): -comparing the incidence of…

Ten years of statin therapy started in childhood: efficacy, safety, compliance and tolerability in patients with familial hypercholesterolemia (AfterTen-study)

This study will evaluate the effect of approximately 10 years of pravastatin treatment on IMT in young adults with FH. Furthermore, safety parameters and psychological aspects with respect to early treatment initiation will be investigated.

Stenting of symptomatic vertebral artery stenosis. A randomised safety and feasibility study

The primary aim of the proposed study is to assess whether stenting for symptomatic vertebral artery stenosis >= 50% is feasible and safe. A secondary aim is to assess the rate of new vascular events in the territory of the vertebrobasilar…

Systemic Mastocytosis and Cardiovascular Risk

Our objective is to assess whether patients with SM compared to controls have more advanced atherosclerosis assessed by carotid intima-media thickness (C-IMT) and carotid plaques and have a more adverse cardiovascular risk profile.

The incidence of endothelial dysfunction and atherogenesis in hemophilia patients with obesity: the Idaho-study

Are overweight or obese patients protected against atherosclerosis when suffering from haemophilia A? Is this association influenced by the severity of haemophilia? When the coagulation activity increases due to obesity (and inflammation), will this…

Arterial properties of ulcerative colitis patients and unaffected controls; a cross-sectional outpatient clinic study.

This study is aimed at understanding status and future cardiovascular disease (CVD) risk in UC outpatients in remission undergoing different anti-inflammatory therapeutic regimens (tofacitinib (a JAK1 - inhibitor), anti-TNF (infliximab or adalimumab…

Prevalence and impact of high on-treatment platelet reactivity in patients with peripheral arterial disease

Primary Objective: Investigate the difference in composite endpoint MACE, major amputation, or target vessel revascularization in PAD Fontaine II patients with and without antiplatelet resistance as measured by a. VerifyNow b. Genetic testing of…