301 results
The main point of this study is to detect in a controlled fashion if there is a relationship between CCSVI and MS. We focus on 5 parameters indicative of CCSVI: 1-reflux in the internal jugular vein (IJV) or in the vertebral vein (VV), or both with…
W want to investigate the influence of a mutaion in the MH allel on the HPV and the normal reaction of MH patients to hypoxia
Primary objectives:1. To determine image quality and diagnostic accuracy of CE-MRV using a new, optimized high resolution 3D T1 weighted volume interpolated gradient echo sequence with fat suppression (THRIVE) with both a blood pool and a…
The main objectives of this study is to see if changes in the innate immune system can be found in diseases associated with increased risk for atherosclerosis
In the current study, we want to demonstrate Rienso uptake in the vessel wall in patients with cardiovascular disease and relate the uptake of Rienso to endothelial permeability.
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
The primary objective of this study is to determine the anti-Xa activity after a reduced therapeutic dose of nadroparin in patients with an eGFR < 60 ml/min in comparison with the anti-Xa activity after a standard therapeutic dose of…
To investigate whether an interactive internet-based intervention strategy targeting vascular and lifestyle-related risk factors can lead to improvement of cardiovascular risk profile and prevention of cardiovascular disease and whether this in turn…
The primary objective for this study is to evaluate the cerebrovascular reactivity of HCHWA-D patients:1. To compare the (autoregulatory) function of small brain vessels in HCHWA-D patients with matched controls using the cerebrovascular reactivity…
This study aims at (further) revealing the pathophysiology of intestinal IR in man, with a specific interest for the role of proteases and protease-activated receptor-2 (PAR-2), cellular and inflammatory changes, barrier function and intestinal…
To characterize phenotypical parameters, cytokine production and epigenetic characteristics of monocytes in patients with diabetes mellitus type 2, stratified according to antidiabetic treatment regime. Ex vivo exploration of the conditions which…
The main objective of this study is to investigate whether a long lasting pro-inflammatory phenotype, the characteristic of trained immunity, is present in circulating monocytes of patients with severe periodontal disease and whether this correlates…
To prevent vessel damage of the radial artery by using the Cordis Railway sheathless guiding catheter system.
The main goal of this study is to assess the difference in local pulse wave velocity measured at three different points in the left and right carotid artery in healthy subjects and in patients with symptomatic and asymptomatic carotid plaques. As…
The primary objective will be the prevalence of medial arterial calcification, defined as an ABI * 1.3 and a TBI > 0.7, among hemophiliacs compared with non- hemophiliacs matched by sex and age.
We hypothezise that hypertension in pregnancy, spontaneous preterm birth and cardiovascular disease in later life share pathophysiological features of endothelial dysfunction. We will investigate this on two levels including local on tissue level…
We aim to i) describe flow patterns and flow-related dynamics in the ascending aorta of patients with aortic valve stenosis, ii) compare these flow parameters before and after surgical aortic valve replacement and iii) compare flow parameters with…
Primary Objective: To assess the analytical performance of the cardiac reader Secondary Objective(s): To assess the user friendliness of the device (handling, analytical speed).
Based on the gaps in our knowledge (as stated above), we have formulated the following objectives:- To quantify the degree of hepatic fat accumulation and fibrosis in patients with HFI. - To gain more insight in the mechanism leading to NAFLD in…
To investigate whether long-term activation of the innate immune system, named *trained innate immunity*, occurs at the level of the bone marrow progenitor cells in patients with significant coronary artery disease and whether this correlates with…