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Assessment of real life and trained inhalation of Tobramycin Inhalation Powder (TIP) and Tobramycin Inhalation Solution (TIS) TIPTIS study.

Primary objective of the study is to record TIP inhalations on video at home to study the association between inhalation manoeuver and cough. Secondary objectives are: To study the inhalation maneuvers of patients using TIP in the home situation; to…

WHEN MAY VARIATION IN DEVIATIONS OF STRABISMUS BE CONSIDERED AS REAL CHANGE?

To investigate inter-examiner variability of the alternate prism and cover test (APCT) measurements of ocular deviation at near and distance fixation, and to compare variability between adults/teenagers and children.

Effects of Trauma Focused Cognitive Behavioural Therapy (TF-CBT) and Eye Movement Desensitization and Reprocessing (EMDR) for children with Posttraumatic Stress Symptoms

The main objectives of the present study are: determining short and long term effects of TF-CBT and EMDR; assessing the efficiency of these therapies; and identifying the characteristics of those children who do not respond to the given treatment.

6 minutes assisted leg and arm cycling test: feasibility, validity, test-retest responsivity and responsivity in patients with neuromuscular and metabolic disorders

2.1 Primary Objectives: 1) To test the feasibility of the six minute assisted leg and arm cycling test in patients aged 6-18 years with Duchenne muscular dystrophy (DMD), Beckers muscular dystrophy (BMD), Limb Girdle muscular dystrophy (LGMD),…

A Multicenter, Multinational, Extension Study to Evaluate the Long-Term Efficacy and Safety of BMN 110 in Patients with Mucopolysaccharidosis IVA (Morquio A Syndrome)

To evaluate the long-term safety and efficacy of BMN 110 administration at 2.0 mg/kg/qw and 2.0 mg/kg/qow in patients with MPS IVA.

Chlamydia Screening Implementation Project

The aim of this pilot implementation is first to make a serious start in Chlamydia screening and secondly to determine feasibility, affectivity and cost-effectivity. The results of this pilot implementation will be leading for the decision about the…

PILOT STUDY: WEB-BASED TREATMENT OF SEVERE FATIGUE AMONG ADOLESCENT PATIENTS WITH AN IMMUNE DYSREGULATION DISORDER: A SINGLE-CASE EXPERIMENTAL DESIGN WITH MULTIPLE MEASUREMENTS.

1. To investigate the feasibility of web-based cognitive CBT among severely fatigued adolescent patients with an immune dysregulation disorder, and 2. To estimate intervention effects on reducing fatigue, associated chronic pain and fatigue related…

*Trauma-informed approach for unaccompanied refugee minors: a multiple baseline case series*

The primary objective of this study is to measure the effectiveness of the TFT for URMs living in the Netherlands. The research question is as follows: is this TFT effective in decreasing symptoms of posttraumatic stress and depression in URMs…

Behavioural activation for depressed adolescents

The present study aims to examine if BA has a positive effect on the severity of depressive symptoms as measured by the PHQ-9 in adolescent depressive participants. In addition, several additional objectives are included (classification of the…

Pegasus: Equine-Assisted Therapy for therapy-resistant adolescents with autism spectrum disorders, a multiple baseline AB-study

OBJECTIVE: To quantify the short-term (15 weeks) and long-term (1 year) (cost-)effectiveness of Equine-Assisted Therapy (EAT) in adolescents with therapy-resistant ASD (aged 11-18) and, when proven (cost-) effective, implement EAT in clinical…

Use of the NMF biomarker as predictive diagnostic for effective use of cyclosporine and dupilumab in the treatment of atopic dermatitis.

The current study has two main objectives:- To investigate if the effectiveness of CsA differs for NMF low vs. NMF normal (corresponding with FLG mutation vs. FLG wild type) in children with moderate-to-severe AD. - To investigate if the…