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The relationship between pain and cognitive functioning, of patients with neurodegenerative diseases such as Parkinson's disease, Multiple Sclerosis and Huntington's disease
Substudy: The relationship between pain, cognitive functioning, and motor activity in patients with multiple sclerosis

Various brain areas play a crucial role in both pain and cognition, supporting the existence of a close relationship between pain and cognition. Consequently, it is important to examine whether pain experience changes at the moment the patient shows…

The retro-orbital fibrobast: a key player in Graves* opthalmopathy and a target for therapy.

Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.

Genes and gene-function in bicuspid aortic valves

The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…

Investigating the genetic building blocks of emotion and behaviour in the general population

This study aims to identify the relationship between candidate genes such as for instance BDNF, 5-HTTLPR, DAOA, G72, DTNBP1, NRG1 and COMT with cognitive function and emotional- and behavioural traits.

Application of cultured autologous keratinocytes in combination with a meshed split skin autograft for burn wound healing

ObjectiveEvaluation of the application of cultured autologous keratinocytes in combination with a meshed split skin autograft to improve burn wound healing

Evaluation of the potential of Real-Time 3-Dimensional echocardiography in the assessment of right ventricular function in patients with congenital heart disease: comparison of RT-3D echo with MRI.

The aim of this study is assessment of right ventricular function: a comparison between MRI and real-time 3-D echocardiography (RT 3-D echo). We have the following research questions: 1) Is assessment of right ventricular (RV) function with RT 3-D…

PENGUIN-trial: pancreatitis, endoscopic transgastric versus primary necrosectomy in patients with infected necrosis. A randomised controlled multicenter observer-blinded trial

To investigate if endoscopic transgastric necrosectomy will lead to a reduction ofthe per- and postoperative pro-inflammatory response, as compared to necrosectomy by laparotomy, in patients with infected (peri-)pancreatic necrosis.

Characterization of veterinary and community acquired MRSA: determinants, transmissibility and virulence

The objective of this study is to identify determinants, to determine the transmissibility and to determine the burden of disease of NT-MRSA and CA-MRSA carriage compared to other typeable MRSA strains in the community.

Research for markers of bone quality

The research is set up to investigate three primary questions.1. Is there a difference between bone resorbing capacity between postmenopausal women with a vertebral fracture and postmenopausal women without a vertebral fracture and high bone mineral…

Open-label, randomised, multi-center study investigating Cetuximab, in combination with concurrent chemo- / radiotherapy in locally advanced non-small cell lung carcinoma

The aim of the study is to assess the feasibility of combined treatment of Cisplatin, Cetuximab and concurrent RT and to get insight in the clinical efficacy (for study schedule, see flow chart 1). The first phase of the study will mainly focus on…

Genomics to combat Resistance against Antibiotics in Community-acquired LRTI in Europe: GRACE Workpackage 9: Study on the aetiology, diagnosis and prognosis of lower respiratory tract infections in primary care

Within the observational study WP9, there will be 3 substudies. First the microbiological aetiology of LRTI will be studied by comparing test results in 3000 healthy controls to findings in 3000 adults with LRTI. Bacterial resistance rates will be…

Psoriatic Arthritis Atopy Study Eindhoven Rotterdam

Aim of this study is to explore the relation between Th1-cell mediated diseases as psoriasis/psoriatic arthritis and Th2-cell mediated asthma, allergic rhinoconjunctivitis, atopic dermatitis and hand eczema. Question is whether a dysbalans in…

A pilot study of immunorespons in children with Down syndrome after Respiratory Syncytial Virus (RSV) lower respiratory tract infections (LRTI)

The primary objective is whether a difference in innate and acquired immunorespons on RSV infection exists, in children with DS compared to healthy matched-controls.

An open, prospective, comparative clinical trial to evaluate the improvement of the colposcopist with the use of DySIS* compared to conventional colposcopy.

Primary:To validate the latest version of DySIS in discriminating high grade (HG) from low grade (LG) lesions and non neoplastic tissue as well as in selecting the most atypical site for biopsy sampling, through digital documentation and…

Validation of a repeated cardiopulmonary exercise test for the assessment of physical impairment in chronic fatigue syndrome.

We need objective and validated tests for the assessment of the severity of impairment in CFS/ME patients. In 2 areas these tests will be essential: for studies of the effect of interventions and for the assessment of disability.Hardly any research…

Prevention of neutrophil induced extracellular matrix damage following skin exposure to solar simulating radiation (SSR)

To investigate the effect of a sunscreen, a topical antioxidant and a topical corticosteroid on erythema, infiltrating neutrophils and oxidative stress following exposure of the skin to SSR.

Radiographic Analysis of the Sagittal Alignment and Balance of the Spine in Parents who have a Child with Adolescent Idiopathic Scoliosis

To investigate whether parents of children with adolescent idiopathic scoliosis have a significantly different neutral upright sagittal alignment compared to adult volunteers whose offspring does not have adolescent idiopathic scoliosis.

B-cell differentiation defects and clinical complications in antibody deficiency syndromes with a focus on Common Variable Immunodeficiency

To detect B-cell differentiation and maturation defects in patients with antibody deficiency syndromes of unknown origin (CVID, SAD), which are predictive for clinical complicationsTo detect and sequence candidate genes in subgroups of patients with…

The role of diurnal cortisol rhythm in relation to personality and QoL with regard to morbidity, prognosis and mortality in patients with suspicion of breast cancer

The aim of the study will be to examine the relationship between personality, QoL and diurnal cortisol rhythm in women with a suspicion of breast cancer with regard to morbidity, prognosis and mortality.

Prestudy Optimizing Diagnosis of Community-Acquired Pneumonia

The objective of the standardized protocol is optimalizing the accuracy of the diagnosis (all-cause pneumonia, or serotype-specific pneumonia) during the 13-valent pneumococcal vaccin (13vPnC) study which will be performed in 2008. Additionaly, the…