70 results
1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…
1. To investigate if PMN of patients with sickle cell disease are prone to form NET when compared to PMN of healthy controls.2. To investigate if red blood cells of sickle cell disease patients promote NET formation of PMN in sickle cell patients as…
Main study:We want to assess whether bleeding risk in women with uterine leiomyomas is associated with CK activity and attenuated platelet aggregation.Objective of pilot study:Firstly, to perform a feasibility pilot of CK/AK measurement in menstrual…
The aim of the project is to examine the association between clinical, environmental and genetic characteristics of the recipient of erythrocyte transfusions and the risk or resistance to immunization against erythrocyte alloantigens that he/she was…
Primary objective- Short- and mid-term repeatability of mDLS and LSCI measures;- Comparison of blood flow obtained by LSCI and blood flow obtained by mDLS;- Comparison of coagulation status obtained by mDLS and coagulation status assessed by…
The objective of this study is to investigate if the Thrombin Generation Curve has an additional, possible more accurate, value besides the conventional tests such as PT, APTT, INR, AT and the mearument of coagulationfactors for determining…
Primary objective:Determine the incidence rate of inhibitor formation in PUPs with severe and moderately severe hemophilia A during the first 50 exposure days (EDs) to starting with a once weekly prophylactic regimen together with the minimization…
To get more insight into the T cell homeostasis in lymfocytopenic, ATG treated patients and normocytopenic patients treated with standard maintenance immunosuppressive drug therapy.
1. To compare the platelet function between healthy controls and patients with ET under both static and dynamic conditions. 2. To study the effects of anagrelide and hydroxyurea on platelet function. 3. To study the intrinsic platelet activation…
The objectives of this study is to determine the recovery and survival of platelet concentrates; in the first phase, a comparison will be made for platelet concentrates in plasma stored for 2-3 days versus those stored for 6-7 days; in the second…
In our laboratory we are able to characterize and culture MSCs. In order to study more extensively the possible alterations in MSC biology in AA we will investigate bone marrow cells of patients with newly diagnosed AA and at the time of response…
Main: Investigate the cyclic variation in clot lysis time in women with HMB in comparison to controls. Secondary:- Investigate the cyclic variation in TAFI, PAI-1, tPA, PI, thrombin generation, fibrinogen, fibrin clot permeability and confocal…
Primary Objective: To assess whether the current use and dosing in cirrhosis of anticoagulation is as effective in inhibiting ex vivo thrombin generation compared to the treatment of patients with competent liver function
MRI vessel wall characteristics of peripheral arteries and arterial stiffness in hemophilia patients
The primary objective is to analyze and compare morphological (media- thickness) and functional (stiffness) vessel wall parameters of peripheral arteries between hemophilia patients with an ankle- brachial index >= 1.3 and hemophilia patients…
The study has 3 objectives: 1. Proving that this form of RCA does not increase the risk of bleeding while achieving a degree of anticoagulation of the extracorporeal system that is similar to that when using LMWH. When this study shows that citrate…
The main purpose of the study is to assess immune cell dynamics in Tecfidera-treated MS patients and untreated healthy subjects, and to explore whether differences in immune cell dynamics exist between both populations. The data generated in this…
To sess the relationship between cerebral perfusion and clinical findings (neurological and neuropsychological) in patients with sickle cell disease.To compare iamging fincdings in children with and without sickle cell disease.
To study whether microcirculatory perfusion is improved by ECMO. Perfusion will be studied before & after ECMO start, during ECMO weaning and before & after ECMO stop. To study the precictive value of perfusion and its correlation…
PrimaryTo assess the prevalence of anti-efalizumab positivity in two sub-populations of psoriatic subjects trated with Raptiva® in the framework of the CLEARESTTM study:- Subjects developing adverse events (AEs) corresponding to pre-specified newly…
The objective of the study is to gain new insights in the causes of a higher clopidogrel resistence in type II diabetes mellitus patients