18 results
The current research is set to provide insight into the phenotypic characteristics of DSPD patients in terms of psychological characteristics, occurrence of co-morbidities, and behavioural characteristics such as bedtime routines and lifestyle, and…
The aim of this study is to investigate the differences between RLS and PLMS.
The current study assesses activation of hippocampus and prefrontal cortex during sleep spindles in veterans with and without PTSD. Furthermore, the correlation between sleep spindles and memory consolidation will be examined.
With this study we aim to investigate the emotional development, behavior, social behavior, variation in personality traits and intellectual functioning in a group of children who are diagnosed with narcolepsy with of without cataplexie, according…
No studies have yet investigated brain activity in NC patients in relation to alertness and sleep resistance. The aim of the current study is to obtain more insight into the regulatory mechanisms controlling alertness and sleep resistance in…
This study aims to further clarify the pathophysiological mechanisms underlying the decreased vigilance, sleep/wake lapses, and the emotional processing leading to cataplexy.
The aim of this study is to examine if an increased number of awakenings in PTSD is PTSD dependent or trauma dependent. Furthermore, the purpose of the study is to examine if the nocturnal excretion of cortisol is increased.
Aim of the study is to investigate what the influence is of insomnia on driving performance and to what extent this influence is attenuated by the use of hypnotics. Therefore, over-the-road driving performance of treated and untreated patients…
Is the muscle weakness during cataplexy due to pre- or postsynaptic inhibition? In other words: what happens with the H-reflex and Magnetic Evoked Potential during REM sleep and cataplexy?
1. To compare energy expenditure in detail between narcolepsy patients and healthy controls. 2. To compare insulin sensitivity between patients with narcolepsy and healthy controls.3. To establish the impact of chronic sodium oxybate treatment (3-4…
The aim of this study is to examine arousals in PTSD, and to investigate the correlation of arousals with nocturnal excretion of hormones of the HPA-axis.
To assess whether a higher ear temperature is related to objective and subjective sleepiness, and subsequent sleep onset in patients undergoing a standard EEG examination. A secondary objective is to investigate whether ear temperature is related to…
The objective is to identify non-invasive neuroimaging biomarkers and mechanisms characterizing different phenotypes of central disorders of hypersomnolence (narcolepsy type 1, narcolepsy type 2 and idiopathic hypersomnia) as compared to groups of…
Our main objective is to assess the difference in PIPR after a blue-light stimulus between hypopituitarism patients with and without a history of CC. Secondary objectives include differences in subjective and objective sleep quality, sleep-wake…
Primary questionAre changes in vigilance in type 1 and 2 narcolepsy, idiopathic hypersomnia and epilepsy with only nocturnal seizures reflected in differences in the responsiveness of the pupils to light as measured by pupillometry (PIPR) versus…
Achieving more detailed information about the possible auto-immune process that underlies narcolepsy by:(1) Assessing differences in immune composition between peripheral blood samples of healthy controls (n=30) and type 1 narcolepsy patients (n=30…
To investigate in people with NT1 and matched controls, after an experimentally induced social stress test:Primary:- Direct HPA activation (plasma cortisol).Secondary: - Direct autonomic stress response (ACTH and HR). - HPA activity and autonomic…
The aim of this longitudinal study is to find new biological, clinical and/or electrophysiological biomarkers in order to define and differentiate individual diagnoses of NT1 and the NBL, and to find improved treatment targets and strategies.