48 results
Objective: We would like to differentiate *normative mood swings*. in adolescence from early signs of depression. A comparison between low-risk adolescents and an at risk and a clinically referred sample is needed to detect an unrecognized subsample…
We aim to answer the following research questions:Primary:1) Is a history of major depressive disorder associated with smaller volumes of the hippocampus and is this volume reduction disproportionate to the total brain volume?2) Are depression and…
We aim to (1) improve differential diagnosis of recurrent MDD and BD by investigating biomarkers at a neuropsychological and neurobiological level ; (2) investigate whether affective neuropsychological testing can be used as a diagnosios tool for…
The study has 3 substudies with each their separate goals:Neuroimaging part:1. To determine the effects of DBS on D2 receptor binding. 2. To determine alterations in cerebral perfusion associated with deep brain stimulation (DBS).Neuropsychological…
This study aims at the questions about anterograde amnesia. How often does it occur in patients being treated with bilateral ECT for a depressive disorder, how does anterograde amnesia develop during the treatment course and how does it subside…
To compare cerebral activity patterns during emotional and cognitive processing among patients with post-MI depression and patients with regular depression.
1) To investigate the impact of keeping/loosing diabetes on quality of life and psychological well-being in a group of (morbidly) obese patients who underwent bariatric surgery, and 2) To explore whether we can predict postoperative quality of life…
Main objectives: This exploratory intervention study is set out to examine effects of tailor-made lifestyle advice, based on observed individual temporal patterns of lifestyle factors and experienced pleasure, as a non-pharmacological means to…
The primary research question is:1. Is there a difference in the usage of memory strategies between both groups?The secundary research questions are:2. Is there a difference between both groups in the types of memory strategies they use or don*t use…
In the present research we will focus on the role of nutrition in the relationship between depression and coeliac disease.
The primary objective of the study is to relate depression and anxiety in CHF patients receiving an ICD to the occurrence of ventricular tachyarrhythmias. Secondary objectives of the study are:Assessment of the effects of depression and anxiety on…
Primary Objective: * To determine the effects of pharmacogenetic screening for CYP2D6 on the time to reach adequate serum drug levels according to the guidelines.Secondary Objective(s): * To determine the effects of pharmacogenetic screening for…
To evaluate the cost-effectiveness of a nurse-led stepped-care program for depression among primary care patients with type 2 diabetes mellitus and/or coronary heart disease and subtresshold depression in comparison with usual care.
Overall, our primary research goal is to elucidate the underlying molecular and cellular neurobiology of depression. Specifically, this study will focus on the following key objectives:1. My first objective is centered on the major prevailing…
This study aims to investigate the neurobiological basis underlying the strong antidepressant effect of ECT in patients with unipolar and bipolar depression using MRI. We will also assess a potential neurobiological basis for the cognitive side-…
To investigate the maintaining factor of mood-congruent memory bias of depression, the circumstances when they occur and the neural correlates of these.
This study aims at gathering conclusive information about the effectiveness and efficiency of the secondDepression Breakthrough Collaborative and to make the results useful to other implementationprograms.This study aims to answer the following…
Primary objective: the primary objective of the present study is to assess whether apathy can be linked to structural brain changes (both atrophy of grey matter, as well as changes in white matter), whether apathy in PD is related to certain…
The study objective is the assessment of influence on glucose homeostasis as a consequence of starting switching, discontinuing or doses changes with antidepressants in a population of diabetic patients.
1) To examine whether adolescents with depression, show abnormalities during specific attentional processes, compared to normal controls, 2) To determine whether abnormalities in attentional processes can be considered as prognostic markers of a…