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Minitub: Prospective registry of Sentinel Node (SN) positive melanoma patients with minimal SN tumor burden who undergo Completion Lymph Node Dissection (CLND) or Nodal Observation

With this prospective registry we aim to evaluate the outcome of patients with a T2-T3 primary melanoma and minimal SN tumor burden, treated by CLND or nodal observation:* The main objective is to determine if T2-T3 melanoma patients with minimal SN…

Age-related changes of the immune system leading to hyporesponsiveness; a major player and predictor for biological behaviour of metastasized melanoma?

To study the frequencies and differentiation status of CD4 and CD8 T cell populations (Tnaive, TCM, TEM, TEMRA) in young (18-50) and old (>65) treatment naive metastasized melanoma patients at baseline and after treatment.

Regulation of skin tumorigenesis by integrin α3β1

The primary objective is to evaluate possible clinical effects correlated with α3β1 and CD151 expression in human epidermal malignancies, and relate these findings to the effects of α3β1 and CD151 deficiencies in skin cancer in the mouse.…

DNA methylation profiling in blood of patients with cutaneous squamous cell carcinoma (cSCC) after organ transplantation

The main objective of this study is to identify changes in DNA methylation of CD3+ T cells associated with cSCC after organ transplantation.

Risk factors for non-melanoma skin cancer (NMSC)
1. Skin carcinoma progression analyzed by genome-wide gene expression profiling and mimicked by validated organotypic in vitro human skin cancer models; towards an integrative system-biology approach and an in vitro screening method for targeted skin cancer therapies.
2. Genetic and environmental risk factors for the development of skin cancer in organ-transplant recipients.

Study 1:The ultimate goal is to abrogate or reduce the excessive burden of carcinomas in organ transplant patients. We aim to elucidate and establish consistent changes in genomic and expression (both mRNA and miRNA) profiles in the course of tumor…

Ultraviolet related DNA-damage in skin of patients with atopic dermatitis and atopic status in relation to the use of Myfortic®

The primary aim is to study the effect of treatment of severe AD patients with Myfortic on DNA-repair after irradiation with UVB.A secondary aim is to study the effect of treatment of severe AD patients on atopic status, measured as total IgE and…

Optical spectroscopy as a novel tool in the diagnostics of skin neoplasms.

Primary Objective: To quantify the tissue light scattering, absorbing and fluorescence properties of different stages of skin (pre)cancer using multi-diameter single fiber reflectance (MDSFR) spectroscopy. Secondary Objective(s): To correlate the…

Longterm carcinogenic effects of daily low emission phototherapy in psoriasis

To ascertain the amount of UV-damage (p53 activation, apoptosis, thymidine dimers and γH2AX) is caused by the Dermasun treatment in psoriasis patients.Total skin check in patients using Dermasun for a prolonged period of time to screen for (pre-)…

Nivolumab dose optimization during nivolumab therapy in melanoma patients after achieving a complete, partial or stable response (NIVOPTIMIZE-trial)

This study has been transitioned to CTIS with ID 2024-516718-39-00 check the CTIS register for the current data. The primary objective is to demonstrate that the nivolumab steady-state level after 3 cycles with a reduced nivolumab dosage (240 mg…

Role of host cell DNA methylation analysis in predicting non-regression or regression of high-grade anal intraepithelial neoplasia in HIV+ men trial (MARINE)

In this study we clinically validate if host cell DNA methylation markers can predict (non-)regression of HGAIN, thus determining the need of immediate treatment versus active surveillance and the safety of withholding treatment. This could prevent…