25 results
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
1. Evaluation of neurocgnitive functioning in children with HIV in comparison with healthy siblings using questionnaires.2. Qualitative analysis of different determinants that play a role in school participation in children with HIV using interviews…
To increase insight in cerebral injury of perinatally HIV-infected children by comparing neurological, ophtalmological and neurocognitive outcomes to those of matched controls (with respect to age, sex, ethnic background, home environment and socio-…
Primary Objective: Create a complete transcriptome of blood cells from dichotomous HIV-2 infection.Secondary Objective(s): Define host factors and pathways that are implicated in the pathogenesis of HIV infection. Determine of the mechanisms that…
We propose to investigate the health related quality of life (HRQoL) in childhood survivors of refractory GvHD who have been treated with mesenchymal stem cell transfusions. This will be a multi center study involving the Division of Clinical…
Immune regulation in Common Variable Immunodeficiency: the role of apoptosis and regulatory T cells.
To gain insight in the regulation of immune responses in patients with CVID
To characterize the profile of low BMD in >= 50 years old male HIV-1 infected subjects andpost-menopausal female HIV-1 infected subjects taking TDF-based regimens relative tothose taking non-TDF-based regimens for HIV infection.
To determine the frequency of MBL and FCN SNPs in patients with a history of a proven gram-positive bacteremia, compared to patients without such history. A secondary objective is to determine whether extracorporeal circuits, used in cardiothoracic…
To evaluate neurologic- and cognitive disorders, neuroimaging and ophthalmological alterations in perinatally HIV-infected children in comparison to matched (with respect to age, sex, race, home environment and socio-economic status) healthy…
Clarifying the qualitative and quantitative aspects of the T cell response targeting and controlling polyomavirus BKV.
To describe the prevalence of enteropathogenic viruses in children with primary (CVID and CVID-like disease) and secundary immunodeficiencies and a potential relation between this prevalence and the development of auto-/allo-immune enteropathy.
To suppress low-level viremia to a level below 50cp/mL in patients using cART by switching their current non-nucleoside reverse transcriptase inhibitor (NNRTI) or PI to DRV boosted with ritonavir (RTV) (DRV/r). Secondary objectives are to reduce the…
To set up a cohort of HIV infected MSM who subsequently acquired HCV infection with a known date of HCV seroconversion to study:- determinants/risk factors for acquiring HCV in HIV infected MSM- the outcome of HCV treatment in this population- the…
Measuring the stability (and thereby half-life) of TRECs.
Primary Objective: The primary objective is to analyse the humoral and cellular immune response to influenza vaccination in PHTS individuals.• Is the immune response to seasonal influenza vaccinations impaired in PHTS?• Do characteristics in humoral…
The main goal of this study is to analyse the influence of the menstrual cycle on NK cell receptor variability.
The main goal of this study is to analyse NK cell phenotype in women with unexplained recurrent miscarriage in relation to their physical health.
To study a cohort of HIV infected and HIV uninfected MSM and HIV infected heterosexuals who (subsequently) acquired HCV infection with a known date of HCV seroconversion:1. To identify the frequency, clinical consequences and determinants (viral and…
Main study: primary vaccination regimenPrimary Objective: 1. To determine the difference in the antibody response against SARS-CoV-2 in PLWH 4 weeks after the completed vaccination schedule with one of the two available mRNA vaccines (BNT162b2 or…
This study is a follow-up study of the NOVICE I & NOVICE II (METC 2012_093 and METC 2016_173). The objective of the study is to both cross-sectionally and longitudinally, after an interval of 10 years, gain more insight into the presence,…