105 results
The overall aim of the study is to improve diagnostic and therapeutic options for people with CF, especially in the context of young children and novel CFTR-targeting drugs. Primary Objective: 1. to demonstrate relations between CFTR genotype,…
Conditions that promote IL-10 producing B cells in humans are still ill defined. In this project our aim is to investigate the frequnecy of IL-10 producing B cells in healthy volunteers. Next, we aim to compare this to the frequency of IL-10…
To assess swallowing and speech function in patients ten years after CRT for head and neck cancer with preventive rehabilitation in order to compare these results with those after six years and to those of patients after CRT without preventive…
The next questions will be addressed in the present study: 1. Do moderately preterm infants differ in development and attention and concentration capacities from a term and very preterm infants during the first years of life? 2. Do attention and…
Dissection of etiology of myopia- identification of genetic risk factors- identification of environmental risk factors- evaluation of the long term safety of Artisan phakic intraocular lenses for the correction of high degree myopia
Primary study objective is to prospectively assess whether the presence of CTCs in the peripheral blood of non-metastatic MIBC patients can identify patients with such a good prognosis not justifying neoadjuvant chemotherapy. Secondary study…
The aim of this project is to determine the possible use of biomarkers for non or delayed union in long bone fractures of the diaphyseal femur and tibia.
The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…
We intend to study the role of fronto-striatal circuitry and cognitive control in the inflexible behaviour that is a defining feature of autism.
We intend to study the effect of trastuzumab on the cardiac neuronal activity in patients with HER-2 positive breast cancer by using iodine-123 meta-iodobenzylguanidine (123I-MIBG) and cardiac imaging. 123I-MIBG, an analogue of the false…
To identify human genetic variants that influence susceptibility or resistance to HIV infection
To evaluate the bowel function, quality of life and nutritional status in adolescents/adults who experienced an episode of NEC at neonatal age.
The objective of this project is to investigate the (cost-) effectiveness of these tailored implementation strategies in comparison to a common used implementation strategy, in a three arm randomized trial.
The primary objective of this study is to demonstrate that free field word recognition scores in quiet and noise with CI *ON* are significantly better than the best aided pre-implant scores in the ear to be implanted (contralateral ear plugged)…
The objective of this study is to investigate the use of retinal oximetry in children, between five and seventeen years of age, with (vitreo-) retinopathies and oxygen-related diseases of the retina by means of an Oxymap T1 fundus camera.
The overall aim of the proposed project is to identify mild PID in elderly patients that distinguish patients with RRTI from individuals with a healthy ageing innate and adaptive immune system. In innate immunity, normal immunosenescence is…
Our aims are to analyse whether there is a specific HLA allele or allelic combination associated with susceptibility to LGI1 encephalitis, and to perform a pilot study with HLA subtyping in patients with encephalitis due to antibodies to Caspr2,…
To explore the role of 4D PET-CT in radiation treatment planning, relative to standard 3D PET-CT.
The objective of this study is to analyse the retinal oxygenation in adults with the Oxymap T1 in patients with amblyopia and untreated or treated (vitreo-) retinopathies and compare them to a reference group of healthy eyes of amblyopic and Coats…
This study will investigate the relationship between autonomic nervous system function and pain in fibromyalgia, with a specific emphasis on awareness of bodily sensations, also refered to as interoceptive awareness, as a potential modulator of pain…