109 results
To determine the maximum tolerated dose (MTD), dose limiting toxicities (DLT), and optimal dose of docetaxel that can safely be administered to patients with cancer in a weekly schedule. amendment 1The objective of the first amendment is to…
Primary Objective• To validate the existing demarcation formula (consisting of psychometric and biological markers) which predicts the sensitivity to Lybrido or Lybridos in women with female sexual interest/arousal disorder (FSIAD with or without…
To determine the influence of the acidic beverage Coca-Cola, concomitantly taken with erlotinib (with or without a PPI), on erlotinib plasma pharmacokinetics compared to erlotinib concomitantly taken with water in cancer patients.
The primary objective of this study is to investigate whether serum taken from volunteers subjected to 30 minutes of helium inhalation can protect different cell types against hypoxia-reperfusion induced damage and to investigate the role of…
The primary objective of this study consists of:To evaluate the HTEA effects on systolic and diastolic cardiac function in rest and after different levels of exercise.The seconderyobjectives of this study consists of:To assess the difference in…
Primary Objective: The primary objective is to determine whether the administration of Gelofusine will reduce the kidney uptake of 111In-labeled exendin in humans by enhancing the excretion of 111In-labeled exendin. These highly relevant data can…
The objective of this study is to evaluate the safety and performance of the ROX Coupler in subjects with resistant hypertension.
To investigate the accuracy of non-fasting lipid profiles versus fasting lipid profiles when lipid lowering therapy is aimed at recommended lipid treatment targets.
Primary:To assess the safety and tolerability of single and multiple oral ascending doses of the study drug in healthy human subjects (Part 1 and Part 2)To assess the effect of food on the absorption and pharmacokinetic (PK) profile of the study…
To study whether the lower cholesterol absorption rates of the Dahlia-2a study were due to lower bioavailability of the oral D7-cholesterol tracer.
To establish if and how the endocannabinoid system is involved in ADHD and related symptoms. This will be investigated by assessing the acute effects of a cannabinoid agonist (THC) on brain function related to ADHD and ADHD symptoms.
Controlling the glycemic impact of food products may reduce glycemic and insulinemic responses. This may result in a decreased inhibition of fat oxidation rate and lower plasma TAG concentration. A higher postprandial fat oxidation may result in…
Primary objectives:To confirm the lack of effect of 0.5 mg sublingual testosterone on physiological and subjective measures of sexual arousal in women with HSDD. Secondary objective:To confirm the lack of effect of 0.5 mg sublingual testosterone on…
The aim of this study is to compare the pain and distress response of children during the application of local anaesthesia injection using a computerized device (the Wand ® or the Sleeper One®) and during the following dental treatment.
The objective of this pilot study is to demonstrate that NAVA ventilation is superior compared to pressure support and pressure control ventilation in work of breathing (expressed as pressure-time product) patient ventilator synchrony and other…
Serum hepcidin levels are elevated in hemodialysis patients and may contribute to functional iron impairment and thus to ESA-resistance. Kinetics of hepcidin in hemodialysis patients has not been studied in detail. This study is designed to provide…
The present project aims to determine the role of DA transmission in novelty-related responses, both behavioral and psychophysiological. Such findings can yield new insights into pathologies in which a disruption of novelty processing is a central…
To investigate the brain responses to images of high and low calorie foods and those during food choice, and to determine gender differences in these responses.
Primary:Part I:- to determine the effects of gabapentin and remifentanil on the evoked area of hyperalgesia, area of allodynia, pinprick hyperalgesia and background pain using a newly developed HCW sensitization modelPart II: - to determine…
To prospectively compare NBI with HRE for the detection and differentiation of polyps in HPS in a large multicentre HPS cohort (n~125).