25 results
PrimaryTo determine whether the palatability of a newly developed formulation of valacyclovir is non-inferior to administration of crushed and suspended tablets in children, is the primary objective of the second phase of the trial.The primary…
Fundamental research with the objective to gain more insight in empathic processes within people suffering from psychopathy. Goal is to evaluate if affective empathic can be temporarily altered (in terms of minutes).
To compare the blood pressure lowering effect of thiazides against calcium channel blockers in CNI-induced hypertension.
The intended result is the discovery of an more effective, more simple, cheaper and more user-friendly treatment for positional OSA than current therapies. Positional therapies have been used as regular treatment in the Amsterdam Wake Sleep Center.…
To find a simple test to explain non-responsiveness to sumatriptan in a proportion of patients with migraine.
Primary Objective: to ascertain whether administered clonidine and scopolamine affect performance (as measured by modulation of reaction times, learning and/or error rates) in a range of cognitive tasks designed to examine uncertainty estimation and…
The aim is to investigate the effects, costs, and feasibility of an evidence-based professional-directed implementation strategy to implement the Dutch peri-operative guidelines, i.e. to achieve a higher adherence to these guidelines. It is…
To study the protective effect of pre-treatment with metformin on flow mediated dilation after 20 minutes ischemia and 20 minutes reperfusion. If metformin treatment indeed limits endothelial IR-injury, a second study will be performed in the same…
We hypothesize that implementation of a workers's health surveillance and consecutive interventions will lead to prevention of injury and disability, health improvement, and eventually sustained employment.
Deep brain stimulation of the nucleus accumbens decreases drug use and craving in treatment refractory heroin and/or cocaine dependence.
The objective is to identify a formulation of ModraCape001 that will release capecitabine in vivo over a time-period of about 18 hours. We hypothesize that prolonged exposure, without a high peak exposure to capecitabine, improves the benefit/risk…
We hypothesize that discriminable responses between oral exposure to caloric and non-caloric stimuli are observed in the following areas: the anterior cingulate cortex, the striatum, the amygdala and areas related to brain reward circuitry (e.g. VTA…
Objective: The overall aim of this project is to investigate acute effects of moderate- and high-intensity exercise in heart failure patients and their age- and sex-matched controls on brachial artery shear patterns.
Part 1: To determine the respiratory response of low and high doses of GAL-021 in conjunction with a low dose of opioids and hypercapnia in healthy subjects. Part 2: To determine the respiratory response of low and high doses of GAL-021 in…
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Hyperglycaemia alters the sustained hypoxic pulmonary vasoconstriction (HPV) and the hypoxic ventilatory response (HVR).
We hypothesise that fasting-induced insulin resistance will result in decreased glucose uptake and activity of brown adipose tissue (BAT). In addition, prolonged fasting will lead to reduced mitochondrial uncoupling in skeletal muscle, which is…
This study aims to investigate the effectiveness of a multicomponent intervention in promoting physical activity among adults with ID.
A high-glucose load can lead to inflammation and it is thought that recurring hyperglycemia may lead to insulin resistance. Our aim is to prevent glucose-induced inflammation and decreased insulin sensitivity with broccoli seedlings which are…
The protein status of an individual effects food preferences and intake. If the protein status is low, products high in protein will elicit greater reward.