322 results
The primary objective of this study is to assess the efficacy of Ecopipam to reduce self-injurious behaviors (SIB) in adults and children with Lesch-Nyhan Disease (LND) in an outpatient setting. The secondary objectives of this study are to assess…
This study is aimed to determine the efficacy of varenicline in reducing EDS in PD patients.
PrimaryTo determine whether the palatability of a newly developed formulation of valacyclovir is non-inferior to administration of crushed and suspended tablets in children, is the primary objective of the second phase of the trial.The primary…
In a fMRI experiment, will measure the changes in brain activity patterns and in functional connectivity. We hypothesize that a subanesthetic dose of S-Ketamine impairs the functional connectivity, especially the feedback connections that are…
To determine the relative bioavailability of pramipexole 4.5 mg tablets vs. 4.5 mg Sifrol in healthy subjects after up-titration.
The aim of this study is to investigate the effect of a single bout of NMES on muscle protein synthesis rates in healthy elderly males.
Primary :To evaluate the prothrombin time (PT) in healthy volunteers treated with edoxaban alone or preceded by apixaban.Secondary : To assess the effect of edoxaban alone or preceded by apixaban on additional pharmacodynamic (PD) assays: activated…
The effect of different flour compositions in a carbohydrate food product on exogenous and total blood glucose.
Primary Objective: 1. Will an exposure to oxygen with a PO2 = 190 kPa lead to changes primarily in DLno compared to DLco?Secondary Objectives: 1. After an exposure to oxygen with a PO2 = 190 kPa for one hour, are the changes primarily located in the…
The aim of this study is to determine the immediate effects of oral alcohol consumption in healthy volunteers on gut wall integrity as measured by Intestinal Fatty Acid Binding Protein (I-FABP) and Lipopolysaccharide Binding Protein (LBP) These…
In addition to our current research in type 2 diabetes patients on oral blood glucose lowering medication, we would like to assess the glucoregulatory effects of different exercise modalities in the impaired glucose tolerant (pre-diabetes) state and…
Research question:Does thin application of betamethasonvaleraat cream 0,1% on perniones lesions twice a day reduce the symptoms of patients as determined in 1st. line health care, with at least 10 mm expressed on a visual analogue scale, together…
The goal of the current investigation is to test the noradrenergic part of a new model that accounts better for results of pharmacological research. This model states that the cholinergic system underlies disengagement, and that the…
The aim of the study is to measure whether there is a difference in LDL cholesterol levels or the 24 hour ambulatory blood pressure in individuals at high risk of cardiovascular disease when the polypill is taken in the morning compared with the…
The objective of the study is to answer the following questions:a) Does the PLS-strategy improve pitch- and speech-perception?b) How does the number of harmonics in consecutive channels influence frequency discrimination, in speech coding strategies…
The objectives of the study are 1) whether ResvidaTM is capable of increasing mitochondrial content and function in healthy obese subject, 2) whether the ResvidaTM induced increase in mitochondrial content and function is accompanied by a better fat…
For a possible (better) treatment of FOG a better understanding of the brainmechanism behind this phenomenon is needed. Previous studies showed some brain areas that are possibly involved in FOG.The aim of this study is to see whether we can induce…
The aim of the present study is to compare the following transport characteristics for a modified 3.86% glucose PET preceded by a long (>8 hours) dwell with 3.86% glucose (PET A) and one preceded by a long dwell with 7.5% icodextrin (PET B),…
The closer examination of acute effects of a single administration cortisol. compared to placebo, on different aspects of attention and other cognitive processing of emotionally relevant stimuli in healthy young men. The central question is what…
Previously we have shown that visual field defects in hemianopes can be reduced by visual training and that it improves performance in daily life activities like reading, car driving (in a simulator), and stimulus identification. Not all patients…