307 results
1) To investigate the effect of atomoxetine on resting-state fMRI measures of network functional connectivity.2) To assess the effect of atomoxetine on several task performance variables, that are hypothesized to reflect tonic LC-NE activity.3) To…
To assess the effect of short term starvation and short term high fat diet on orally administered acetaminophen metabolism in healthy subjects.
The main objective of our study is to explore whether LTH and FMD are correlated. Main secondary objectives are to investigate whether the LTH response is largely NO-mediated and whether drinking beetroot juice acutely improves both FMD and LTH.
To investigate the ability of PF-06372865 to demonstrate analgesic properties in healthy subjects for pre-specified primary endpoints using a panel of pain tests.
To evaluate the effect of intranasal esketamine 84 mg on cognition, and duration of cognitive effects (if present), as assessed using a computerized test battery (Cogstate®).
Primary Objective is to compare the effect of different exercise protocols on intestinal permeability and on plasma levels of glutamine and glutamine-derived amino acids, in healthy young men. A Secondary Objective is to assess the effect of…
In this research we want to determine whether patients prefer the ProTrach DualCare over other speaking valves, if it improves quality of life, compliance with HME use and lung function.
1. To assess whether acute TRPV1 activation by capsaicin or ENaC down regulation by flavonoids modulate osmoregulation in healthy subjects2. To assess whether capsaicin and flavonoids affect blood pressure
The main objective of this study is to investigate the effect of a single tDCS session in children with mild CP on different motor tasks. The second objective is to identify the optimal site of stimulation. In tDCS research the electrodes can be…
Determining the effect of short term ProManna intake on physiological parameters, notably biomarkers of oxidative stress. This pilot study serves to investigate whether ProManna intake leads to any changes in baseline levels for oxidative stress…
To study the effect of fructo-oligosaccharides on functional constipation.
Study I: To assess the bioavailability of Zinc from full cream UHT milk, fortified full cream UHT milk, a supplement, and raw milk.Study II: To assess the potential enhancing effect of milk on Zn absorption from intrinsically labelled rice (as a…
To determine the influence of the acidic beverage Coca-Cola, concomitantly taken with erlotinib (with or without a PPI), on erlotinib plasma pharmacokinetics compared to erlotinib concomitantly taken with water in cancer patients.
Part 1: Quantification of individual patient-prosthesis interactions- Determination of the instantaneous effect of prosthetic knees with variable biomechanical properties on the gait pattern of PULAs (Part Ia). - Determination of the influence of…
To investigate if the active product shows a postprandial plasma triglyceride profile different from the control product in healthy adult male volunteers.
To investigate whether increased aldosterone levels in obese individuals lead to impairment of microvascular function through reduction of NO-availability, and to establish the role of microvasculaire dysfunction in the pathogenesis of salt-…
The main objective is to gain insight into the temporal differences between the perceived sweetness and irritation of carbonated beverages with sucrose and/or Stevia. More specifically, objectives of part 1 of the study are:- To assess the overall…
Our objective is to assess the effect of TRP depletion on mood and behavior in PD patients treated with STN DBS. By doing, this, we hope to be able to identify risk factors for and mechanisms underlying psychiatric side effects of STN DBS.…
Primary Objective: Compare achievement of glycemic control in SSI therapy and NPH insulinGlycemic control is defined as the proportion of glucose measurements within target range (Fasting target glucose 3.9 * 7.8 mmol/l. Random target glucose 3.9-10…
The primary objective is to compare the efficacy of two dose-schedule arms(s) of pacritinib (pooled once daily [QD] and twice-daily [BID] dosing arms) with that of best available therapy (BAT) in patients with thrombocytopenia and primary…