179 results
To compare progression-free survival (PFS) between the two treatment arms based on assessments by an independent review facility (IRF).
Primary:To assess the safety and tolerability of single and multiple oral ascending doses of the study drug in healthy human subjects (Part 1 and Part 2)To assess the effect of food on the absorption and pharmacokinetic (PK) profile of the study…
Primary objective: to determine the effect of intake of one dose of isoflavones, as compared to placebo, for eight weeks on gene-expression in Peripheral Blood Mononuclear Cells (PBMCs) in post-menopausal, equol-producing women.Secondary Objectives…
Primary objective:- to investigate the safety and tolerability after a single oral dose in healthy men and women of non-childbearing potential. Secondary objective:- to investigate the pharmacokinetic of a single oral dose in healthy men and women…
• To determine the onset of action of IN MDZ as compared to IV MDZ.• To determine extend and duration of the sedative effects of 2.5 mg and 5 mg IN MDZ. • To estimate the absolute and relative bioavailability and dose proportionality of single doses…
Bioavailability of micronutrients in special dressings.
We hypothesize, that during an oral glucose tolerance test, the OPS arterial flow measured sublingual will be comparable within the same subject, but different between young, elderly and type 2 diabetic patients. Objective is to quantify differences…
Specific research objectives:Investigate the effect of orally administered citrulline at:- Circulation of gastrointestinal (GI) system- The occurrence of GI damage, liver and kidneys- The GIpermeability - Production of amino acids- Endothelial…
Primary objective: to compare changes in endothelial function in patients with obesity related hypertension after 8 weeks of treatment with aliskiren, moxonidine and HCTZ. Secondary objectives: to compare changes in the following parameters in…
The primary objective of this study is to determine the effects of aliskiren, as compared to ramipril, on renal hemodynamics in overweight/obese and hypertensive patients.
To obtain more information about the effects of capsaicin and cinnamaldehyde on the intestine, these substances will be infused directly in the duodenum. Hereafter, the permeability of the intestine, gallbladder motility and the effects on satiety…
The main objective of this study is to assess the acute effect of co-ingested vinegar on postprandial plasma glucose levels in type 2 diabetes patients.
Our main objective is to determine the effect of HO-1 induction by heme arginate infusion on insulin resistance and endothelial dysfunction related to MetS. Secondary objectives are to determine the effect on adipose tissue, adiponectin plasma level…
The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects <60 kg with stable coronary artery disease (CAD) versus the…
The main objective is to gain insight in unconscious responses to food aromas ultimately to increase the consumption of healthy, but often disliked food products such as vegetables.
The main aim is to develop an intervention to change knowledge, communication and attitudes regarding renal replacement therapy (RRT). The second main aim is to investigate whether this intervention has an impact on the proportion of patients…
The main aim of this study is to collect normative data on the RANDI for several age groups.
The primary objectives are formulated to investigate the effect of chocolate flavanols on vascular function, inflammation, oxidative stress and markers of endothelial function. The effects of both acute consumption and prolonged consumption will be…
- To educate adolescents about clinical drug studies by involving them as project team members and participants in a class experiment with negligible risk and minimal burden;- To educate adolescents about the effects of a low (*social*) dose of…
The aim of the study is to assess the risk of impaired driving in the morning at 3 and 4 hours after a middle-of-the-night dose of zolpidem tartrate sublingual tablet 3.5 mg.