151 results
Determinination of the added effects of dietary sodium restriction or diuretic use to antihypertensive and antialbuminuric therapy.
D1. Comparing the made distance in meters within a fixed time between a walker and a walk-bike used by COPD patients.D2. Comparing the walking time and distance on an outdoor track between a walker and a walk-bike used by COPD patients.
We will evaluate the acute effects of GH on, and its relation with, cognition in healthy subjects. The present proposal focuses on the following questions:1. Does an acute rise of plasma GH levels have a (beneficial) effect on cognitive performance…
The aim of this study is to improve 6MP treatment in pediatric leukemia patients, by developing and licensing a pediatric liquid formulation of 6MP, assessing its stability and bioequivalence, and ensuring a nationwide introduction of the new…
The aim of the study is to compare magnesiumhydroxide and polyethylene glycol/electrolytes with regard to the prevention of constipation and side-effects in palliative care cancer patients starting with opioids.
Primary objective:To assess whether a single day infusion of the GLP-1 RA exenatide, as compared to placebo, reverses GC-induced impairment of glucose metabolism and beta-cell function in healthy males
The goals of the proposed study are: (1) to further elucidate the relations between impulse control, motivational strength of drug cues, and brain activation patterns (using fMRI); (2) to examine the relative strength by which these processes are…
Primary objective: To determine the pharmacokinetic profile of lopinavir and ritonavir in two differ-ent co-formulations (Lopimune granules and Lopimune tablets) after single-dose in HIV-negative, healthy adult subjects, and to compare this to the…
To what extend should a possible worsening of the OSA condition, caused by an increase of mouth opening and partial palatinal coverage, be taken into consideration in daily dental practice, when an occlusal splint is placed in the mouth.Amendement:…
The combination of simvastatin 10 mg/ezetimibe 10 mg has a beneficial effect on post prandial endothelial function in comparison to monotherapy with simvastatin 80 mg.
The primary objective of the study is to determine the gain in effectiveness of TE compared with P when applied to remove excess iron during maintenance therapy of HH patients.
In this study we will be looking at the effects of the different administration routes on release of satiety hormones by the small intestine.
The aim of this study is to determine whether subcutaneous administration of insulin detemir, as compared to NPH insulin, leads to a more pronounced effect on brain glucose metabolism and blood flow in brain regions associated with appetite…
The main objective is to demonstrate the activation of the efferent inhibitory cortico-olivocochlear pathway with otoacoustic emission of the ear contralateral to the side of stimulation with TMS. We expect the amplitude to decrease after TMS of the…
Analyze the protective effect of levocetirizine (LEV), through the direct antagonism of airway H1 receptors and the inhibition of the release or production of other inflammatory mediators, against exercise induced airway obstruction.
Project 1: To investigate the neuroanatoimical correlates of attentional processing bias in nicotine addicts, using fMRI.Project 2: To examine whether attentional biases are dependent on dopaminergic transmission in the mesolimbic system using…
To investigate if the GH-promoting effect of gelatine- protein is present in non-overweight and overweight elderly people.
The primary objective of this study is to determine whether ACE inhibition results in an improvement of microvascular glycocalyx-thickness in patients with type 1 diabetes. The secondary objectives are to investigate whether this (hypothesized)…
1. To test feasibility of mannitol inhalations in a Dutch pulmonary out-patient clinic.2. To compare time and costs involved in measuring airways hyperresponsiveness by methacholine to mannitol
The aim of this research is to determine the effect of glucose in the small intestine on the secretion of hormones, appetite related feelings and food intake, and whether these effects differ between time of day (morning vs evening) and segment of…