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Respiratory effects of tapentadol and oxycodone assessed by pharmacokinetic-pharmacodynamic and response surface modeling in healthy volunteers

To construct the utility surfaces of tapentadol and oxycodone.

A randomized, placebo and active comparator (oxycodone)-controlled study on the effect of tapentadol on respiration and analgesia in healthy volunteers

The objective of this study is to investigate the extent of respiratory depression at equi-analgesic dosages of tapentadol and oxycodone