36 results
The aim is to investigate the effects, costs, and feasibility of an evidence-based professional-directed implementation strategy to implement the Dutch peri-operative guidelines, i.e. to achieve a higher adherence to these guidelines. It is…
Hypersalivation or sialorrhea is one of the most frequently occuring side effects of clozapine use with an incidence ranging from 30 to 90%. In most cases it occurs at the start of clozapine treatment, mostly at night and persists during further…
We hypothesize that in this short term study the testproducts with added fibre will increase satiety, slower gastric emptying, will give a later blood glucose peak and that it will decrease energy intake when compared to the controlproduct.
We hypothesize that implementation of a workers's health surveillance and consecutive interventions will lead to prevention of injury and disability, health improvement, and eventually sustained employment.
1. Evaluation of pulmonary deposition of inhaled Tobramycin with 99mTc-DTPA tracer is feasible using SPECT-CT scans; 2a. Pulmonary deposition of Tobramycin improves with concomitant inhalation of carbon dioxide enriched ambient air; 2b. Pulmonary…
The goal of the study is to: 1. Improve daily functioning in patients with schizophrenia; 2. To improve behavioral observation in psychiatric nurses; 3. To implement CAT in the usual treatment of patients with severe mental illness.
Deep brain stimulation of the nucleus accumbens decreases drug use and craving in treatment refractory heroin and/or cocaine dependence.
Objective of this study is to assess the sensitivity of performance in a number of widely used tests for measuring driver impairment to the dose-effects of alcohol.
The objective is to identify a formulation of ModraCape001 that will release capecitabine in vivo over a time-period of about 18 hours. We hypothesize that prolonged exposure, without a high peak exposure to capecitabine, improves the benefit/risk…
We hypothesize that discriminable responses between oral exposure to caloric and non-caloric stimuli are observed in the following areas: the anterior cingulate cortex, the striatum, the amygdala and areas related to brain reward circuitry (e.g. VTA…
Objective: The overall aim of this project is to investigate acute effects of moderate- and high-intensity exercise in heart failure patients and their age- and sex-matched controls on brachial artery shear patterns.
The main objective is to investigate whether high frequency low dosage IVIg treatment is more effective than low frequency high dosage as maintenance treatment for CIDP. The secondary objective is to investigate whether high frequency low dosage of…
Part 1: To determine the respiratory response of low and high doses of GAL-021 in conjunction with a low dose of opioids and hypercapnia in healthy subjects. Part 2: To determine the respiratory response of low and high doses of GAL-021 in…
It is hypothesized that foods that have an intrinsic nutrient-rich matrix are less susceptible to changes in reward value due to replacing the sugar content than foods that have intrinsic a nutrient-empty matrix. Thus we expect that the reward value…
Amlodipine is prescribed off-label for paediatric patients, but there is no safe, efficacious and appropriate paediatric formulation available. Therefore, an appropriate amlodipine besilate oral liquid 0,5 mg/ml is developed. In order to establish…
Healthy volunteers and patients with a high variability in pain scores have a high probability to experience pain relief from alfentanil opposed to volunteers and patients with a low variability in pain scores.
Patients will prefer power scalers over hand instruments.
1. The deafferentiation during spinal anesthesia changes the connectivity in resting-state networks in healthy volunteers; 2. The deafferentiation during spinal anesthesia changes pain perception and has sedetive effects.
Oral exposure time and energy content of the gastric load both affect subjective feelings of satiety and gastric emptying rate. It is expected that a longer oral exposure time and a higher gastric energy content would both increase subjective…
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