46 results
We hypothesized that FFA loading could impair mitochondrial function and that the potency of FFA to disturb mitochondrial function and glucose uptake would depend on the degree of desaturation of the fatty acids infused.
Microalbuminuria in diabetes mellitus is not only associated with progression to renal disease, it is also a potent predictor of cardiovascular disease and thus may reflect widespread vascular damage. Endothelial dysfunction is one of the first…
Part 1: Previously, the use of a rollator has been shown to improve functional mobility in patients with COPD. We hypothesize that a new walking aid will result in a larger improvement in 6-minute walking distance as compared to the rollator.…
The exerted pressure on the skin by non-invasive pelvic circumferential compression devices (PCCDs) carries a risk of pressure sores and skin necrosis in case of prolonged use. A persons Body Mass Index (BMI) is of influence on this risk.
We hypothesise that aspirin 100mg at bedtime decreases tension by nocturnally lessening increase of the renin-angiotensin-aldosterone system, enhancing NO bioavailability, lessening autonomous nervous system activity or inhibiting COX-1 dependent…
The CPC-mouthrinse inhibit 15% less of 'de novo' plaqueformation compared to a placebo and hexitine over a period of 3 days in a non-brushing model.
Showering shortly after application of Androgel does not negatively affect testosterone plasma levels.
Long-chain triglyceride (LCT) emulsions with very small droplet sizes (fine emulsion) will lead to enhanced postprandial satiety and reduced energy intake in a subsequent meal, as compared to LCT emulsions with relatively large droplet sizes (coarse…
The infusion of intrathecal baclofen using higher flow rates results in more extensive intrathecal distribution, hence benefits pharmacodynamic properties of baclofen
THC causes changes in resting state brain activity that can be visualized by fMRI
In this study we will compare three method to assess the magnitude of the ventilatory response; our hypothesis is that different methods will yield different results.
In the present study we will investigate the efficacy of Lybrido and Lybridos in one group of subjects with FSD using SSRIs in the laboratory and in the domestic setting of these subjects. We will measure subjective, physiological and…
Inhalation of delta9-THC will modulate activity in functional brain systems, including the reward system, the working memory system and the associative memory system.
We hypothesize that oral glucose intake and consequently the endogenous induced hyperinsulinemia will lead to insulin-induced microvascular dilatation in healthy normotensive subjects. Furthermore, we suggest that the insulin-mediated microvascular…
What is the effect of carbohydrate infusion on food choice, food intake, satiety, hormones, dependent on the time of day and segment of the small intestine?
Investigate whether DWIBS is effective for colorectal cancer screening.
Comparison of the gastrointestinal tolerance of two enteral nutrition formulae
The main objective of this study is to investigate to what extent the acute effects of MDMA on cognitive function, prolactin and cortisol levels, body temperature, heart rate and blood pressure are influenced by co-exposure to THC.
This study is designed to study the contribution and quantification of norketamine for its analgetic and psychomimetic effects