46 results
This study aims to determine to which degree the offered help - according to our treatment program - for familymembers and partners of murdered persons helps to treat complicated grief and PTSD (Murphy, 2006, Shear et al 2006) and to gain insight…
To test whether a short FD protocol can be used to test whether effects of light on alertness, sleep, metabolism and temperature are under circadian control.
This study concerns research into the applicability and effectiveness of CBM-I training through an app on the mobile phone. The research is done in adolescents (12-18 years) treated at the Bascule clinic for OCD. The training will take place during…
We will identify factors that interfere with the beneficial effects of exercise on the vasculature in T2DM.
Based on the positive effects of Celecoxib on ultrafiltration and peritoneal injury during PD in rats, we would like to propose a pilot study using Celecoxib in PD-patients. In this pilot study we will investigate whether the Cox2 inhibitor…
The aim of the study is to measure whether there is a difference in LDL cholesterol levels or the 24 hour ambulatory blood pressure in individuals at high risk of cardiovascular disease when the polypill is taken in the morning compared with the…
To gather data to support global submissions/approvals for some models of the Ingenio device family.
Primary Objectives:1. To compare the magnitude of baseline (or intrinsic) platelet reactivity between T2DM patients and healthy volunteers using multiple platelet function assays 2. To compare the magnitude of baseline (or intrinsic) platelet…
To evaluate the effects of long-term intranasal oxytocin on social behaviour in children with PWS and to compare the effects of different doses and frequencies of oxytocin administration
To determine whether addition of selexipag to current PAH therapy improves exercise capacity, imaging parameters and quality of life, delays time-to-first-PAH-related morbidity and mortality, prevents worsening of World Health Organization…
The primary objective is to evaluate the lab transferability of the exercise model as used in the GRINTA! study. This will be achieved by comparing the effect of exercise on biomarkers in blood, urine and saliva in two different laboratories. These…
To elucidate in the same participants (late chronotypes with at least two hours of social jetlag) the changes in sleep timing, social jetlag and endogenous circadian phase of melatonin with more than two hours of social jetlag shielded from blue…
Objective: To test the efficacy and safety of percutaneous renal sympathetic denervation of the native kidneys in the treatment of uncontrolled hypertension in kidney transplant recipients.
Primary objectives: this study will 1) assess the accuracy of the Cortex MetaLyzer® 3B in adolescents (12-17 yr) for measuring REE, using the Deltatrac® II metabolic monitor as a reference; and 2) assess the accuracy and the within-subject, within-…
The primary objective of this confirmatory study is to investigate the acid neutralisation action of Gaviscon Double Action Tablets versus placebo tablets, within the stomach.The secondary objective of this study is to assess the safety of the test…
The aim is to test whether EM in EMDR contributes to a reduction in dysfunctional beliefs about recalling the traumatic memory. A sample of Dutch veterans diagnosed with PTSD will be tested. During three EMDR treatment sessions we will measure…
Serum hepcidin levels are elevated in hemodialysis patients and may contribute to functional iron impairment and thus to ESA-resistance. Kinetics of hepcidin in hemodialysis patients has not been studied in detail. This study is designed to provide…
The objective of this study is to test whether meat structure plays an important role in protein digestion, to maximise the amino acid availability and to stimulate the muscle protein growth in elderly people.
The objective of the study is to investigate whether the Out-Of-Office BPM device of Microlife, the WatchBP O3, is comparable to the Spacelabs 90217 device at 24h BP measurement. Secondary objectives: To investigate whether the implemented features…
1) To assess insulin sensitivity and response in critically ill septic neonates and children. 2) To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or…