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Multicenter randomized 2x2 cross-over study for patient satisfaction and function of the ProTrach DualCare

In this research we want to determine whether patients prefer the ProTrach DualCare over other speaking valves, if it improves quality of life, compliance with HME use and lung function.

respiratory muscle activity during mechanical ventilation and spontaneous breathing trials

To optimize ventilator support in critically ill patients admitted to the intensive care unit by monitoring electromyography of the respiratory muscles.

The efficacy of the walk-bike on quality of life and exercise capacity in patients with idiopathic pulmonary fibrosis: a pilot study.

Primary objective• To assess the effect of use of a walk-bike in IPF patients for 8 weeks on health-related quality of life, measured with the St. George Respiratory Questionnaire, at baseline, week 9 and week 18, in patients with IPF.Secondary…

A Multi-center, Prospective, Randomized, Controlled Single Arm Investigation of Endobronchial Valve (EBV) Therapy vs. Standard of Care (SoC) in Homogeneous Emphysema.

Primary objective:To evaluate pulmonary function (FEV1) at 3 months following placement of Zephyr endobronchial valves in subjects with homogeneous emphysema.Secondary objectives:Evaluation of quality of life, exercise capacity, dyspnea incl. BODE,…

Treatment in patients with recurrent infections and IgG Subclass Deficiency, and/or Deficient Anti-Polysaccharide Antibody Response.

The primary objective of the study is to compare the efficacy of intravenous immunoglobulin product with the efficacy of antibiotic treatment in patients with recurrent respiratory infections and IgG-subclass deficiency and/or selective anti-…

The role of diaphragm muscle EMG monitoring on respiratory physiology in mechanically ventilated patients with ARDS: a pilot study

The objective of this pilot study is to demonstrate that NAVA ventilation is superior compared to pressure support and pressure control ventilation in work of breathing (expressed as pressure-time product) patient ventilator synchrony and other…

Study evaluating ease of use, preference and satisfaction of two different Fluticason/salmeterol inhalers in asthma or COPD patients

To assess the percentage of COPD and asthma patients correctly (all critical items correct) using the Accuhaler/Diskus vs Elpenhaler inhaler devices after reading the package insert. Also satisfaction with and preference for an inhaler will be…

The effect of a walking bike on exercise capacity in patients with COPD and chronic heart failure

Primary Objective: In 2 study groups, patients with COPD and patients with chronic heart failure:• To investigate whether, in comparison to unaided walking, the increase in 6 minute walking distance (6MWD) using a walking bike is greater than the…

Changes in VC, DLCO, DLNO and exhaled breath after an one-hour oxygen dive with a PO2 of 190 kPa as an indication for pulmonary oxygen toxicity.

Primary Objective: 1. Will an exposure to oxygen with a PO2 = 190 kPa lead to changes primarily in DLno compared to DLco?Secondary Objectives: 1. After an exposure to oxygen with a PO2 = 190 kPa for one hour, are the changes primarily located in the…

Validation of a new protocol for the methacholine provocationtest in patients with hyper-reactive airways.

The aim of this study is to compare the PD20 values measured with the Vilbiss 646 jet nebulizer protocol and with the MedicAid nebulizing protocol in 20 subjects with respiratory symptoms suggestive of bronchial hyperreactivity.

'Air to walk'
A study focussing on the effects of 2 walking aids on the functional mobility in patients with moderate to very severe chronic obstructive pulmonary disease (COPD)

D1. Comparing the made distance in meters within a fixed time between a walker and a walk-bike used by COPD patients.D2. Comparing the walking time and distance on an outdoor track between a walker and a walk-bike used by COPD patients.

An open label, part-randomised, four-way crossover, single and repeat dose study to determine the dose proportionality and absolute bioavailability of fluticasone furoate (FF) when administered as FF inhalation powder from the novel dry powder inhaler in healthy subjects.

The purpose of the study is to investigate to what extent blood concentrations of Fluticasone Furoate increase proportionately to rising doses of Fluticasone Furoate in three steps administered via a powder inhalator. In addition, the absolute…

A single-center, open-label, randomized, two-period, two-treatment, crossover study in healthy male subjects to demonstrate bioequivalence of 1600 mcg selexipag administered as eight tablets of 200 mcg (reference drug) or as single tablet of 1600 mcg (test drug)

- To demonstrate bioequivalence of test drug and reference drug - Safety and tolerability- Investigate phamacokinetic properties of selexipag and its metabolite

Oropharyngeal space in videolaryngoscopy: a randomised crossover trial measuring remaining space adjacent to the video laryngoscope blade.

Measuring the space on the right side of the videolaryngoscope blade and the palatopharyngeal wall in a cohort of ASA I-III patients with a normal mouth opening (Mallampati I, II and III). We also want to investigate how this space differs from the…

Short Term Effect of a Heat and Moisture Exchanger on Tracheal Mucociliary Clearance in Laryngectomized Individuals

Primary: Assessment of the short-term effect of a Heat and Moisture Exchanger on tracheal mucociliary clearance in laryngectomized individuals. Secondary: The relationship between clinical assessment, ciliary activity and mucociliary clearance.

Forces exerted on upper and lower teeth during intubation: a randomized crossover trial comparing indirect videolaryngoscopy to direct laryngoscopy

Measuring the forces exerted on upper en lower teeth during classic (direct) and (indirect) (video)laryngoscopy.

Randomized crossover comparison of mask leak between facemask and nasal mask ventilation; a pilot study.

To compare the occurrence of significant mask leak when using a nasal mask versus a facemask in preterm infants needing positive pressure ventilation.

Validation of the Dutch Language Asthma Control Test (ACT) and Child-ACT for internet use among adolescents (ACT) and parents and children (Child-ACT)

The aim of the proposed study is to conduct an evaluation of the validity of web-based completion of the (Child-) ACT on the basis of comparison with paper-based completion and to test reproducibility of both web-based and paper-based version.…

The effects of nanoparticles and ambient particles on brain function using quantitative electro-encephalography (QEEG) in healthy volunteers

To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…

Temporary limited peak pressure increase following endotracheal suctioning in ventilated patients.

the aim of the study is to assess whether short lived limited increases in airway pressure are sufficient to combat ET suction induced hypoxemia