19 results
This study aims to determine the effect of nocturnal versus daytime cyclic infusion of parenteral nutrition in adult chronic intestinal failure patients on bone turnover, glucose metabolism, nitrogen balance, sleep and wake rhythm and clock genes…
This study investigates how well the combination of the two drugs, zibotentan and dapagliflozin, works for the treatment of chronic kidney disease in patients. We compare the effect of zibotentan and dapagliflozin with the effect of a placebo. The…
Part 1:Primary Objective- To investigate whether repeated dose GRX-917 reduces panic symptoms elicited by an experimental 35% CO2 -induced fear challenge administered in healthy CO2-sensitive subjects. Secondary Objectives- To investigate whether…
The primary is to investigate to the change in exposure to cabozantinib by taking cabozantinib with a light breakfast compared to taking cabozantinib in fasted state. The secondary objectives are to investigate the analytical feasibility of…
Establishing efficacy of MFB DBS for TRD by comparing active DBS with sham DBS. Secondary aims are establishing an adverse events profile, establishing effects on quality of life, cost-effectiveness, (neuro)psychological and neuroimaging measures.
The aim of this study is to determine whether treatment with spinal cord stimulation in patients with refractory angina pectoris leads to a significant reduction in myocardial ischemia. Other aims are to determine the effect of this treatment on the…
The purpose of the study is to demonstrate the safety and effectiveness of adaptive DBS (aDBS) for Parkinson*s disease.
Primary objective: To evaluate the efficacy of targeted lung denervation (TLD) in addition to optimal medical care to reduce moderate or severe exacerbations and related hospitalizations, compared with optimal medical care alone, in subjects with…
Given the limited effectiveness of available EGFR TKIs in patients with NSCLC with EGFR exon 20 insertion mutations, this subset patient population is routinely treated with chemotherapy, similar to patients with no driver mutations (ie, WT EGFR).…
In this project we aim to investigate whether we can precisely measure the changes in fermentation gas patterns after supplementation of a complex fibre mixture over a 36-hour period in both lean normoglycemic and insulin resistant and/or…
The primary objective of the study is to determine whether AVIM therapy in combination with medical therapy is more effective at reducing ambulatory systolic blood pressure (aSBP) and to determine whether AVIM therapy is safe.
The present study compares the postprandial amino acid uptake kinetics between a commercially available (fermented) yoghurt vs a commercially available (pasteurized) milk matched for protein, and small differences on fat, calories, and volume.
Four hypotheses will be investigated. First and second, we will evaluate whether treatment with hvHDF has dissimilar effects on the SSC and MC function, if compared to HD. Next, we will assess whether disorders of the SSC and the MC are influenced…
This study aims to test if weak electric fields, as they occur during tACS, desynchronize somatosensory evoked potentials. Further, if they can, it aims to quantify at which tACS amplitude the desynchronization occurs.
To assess the impact of using breathing instructions while performing motion-compensated MR imaging of lesions in the thorax or abdomen aimed at radiotherapy treatment planning as compared to motion-compensated scans without instructions and free-…
The aim of the PISCES study is to evaluate the long-term effectiveness of SCS by comparing a paresthesia-free form of stimulation that the patient does not feel, with sham stimulation in which no stimulation is given. The study will focus on…
The primary objective of the study is to assess the performance of the updated algorithm software. The secondary objectives are to assess the safety and other performance parameters of the updated software algorithm. Additionally, another secondary…
The purpose of this study is to investigate how the uptake and elimination from the body (this is called pharmacokinetics) of a combination oral contraceptive (COC; 100 µg levonorgestrel and 20 µg ethinyl estradiol) is affected by the…
Primary: effects of SAF312 on the Maximum Cystometric Capacity (changes from baseline) versus placebo following one-week treatment.Secondary: Evaluation of the safety, tolerability and PK, PK/PD, additional parameters examined during cystometry,…