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A Study to Assess the Effects of the Endothelin Receptor Antagonist Zibotentan and the SGLT2 Inhibitor Dapagliflozin in Patients elevated Albuminuria: a Randomized Double Blind Cross-Over Trial

This study investigates how well the combination of the two drugs, zibotentan and dapagliflozin, works for the treatment of chronic kidney disease in patients. We compare the effect of zibotentan and dapagliflozin with the effect of a placebo. The…

The pharmacological effects of using cabozantinib with a light breakfast

The primary is to investigate to the change in exposure to cabozantinib by taking cabozantinib with a light breakfast compared to taking cabozantinib in fasted state. The secondary objectives are to investigate the analytical feasibility of…

The Effect of Ketone Monoester on Cognition in Neurotypical People of Different Ages

The general objective of this study is to investigate whether ketone monoester supplemention improves cognition. Cognition will beassessed by adaptive n-back test and task-switching test. The study will also investigate the effect of ketone…

A multi-center, double-blind, randomized, placebo-controlled, cross-over study to evaluate the efficacy, safety and tolerability of SAF312 in subjects with neurogenic detrusor overactivity due to spinal cord lesions who are inadequately managed by antimuscarinic therapy (CSAF312A2202)

Primary: effects of SAF312 on the Maximum Cystometric Capacity (changes from baseline) versus placebo following one-week treatment.Secondary: Evaluation of the safety, tolerability and PK, PK/PD, additional parameters examined during cystometry,…