17 results
This study is aimed to determine the efficacy of varenicline in reducing EDS in PD patients.
Primary Objective: 1. Will an exposure to oxygen with a PO2 = 190 kPa lead to changes primarily in DLno compared to DLco?Secondary Objectives: 1. After an exposure to oxygen with a PO2 = 190 kPa for one hour, are the changes primarily located in the…
The primary study objective is to assess the hypoallergenicity of an extensively hydroloyzed whey protein infant formula in children with cow's milk allergy.The second study objective is to assess the long-term effects on growth and tolerance…
Primary objective:The primary objective of this study is to evaluate the effect of LCM 200mg bid on the single dose PK and PD of a single warfarin 25mg dose.Secondary objective:The secondary objective of this study is to monitor the safety and…
Primary: to assess the bioequivalence of LH after administration of the freeze-dried (FD) Luveris formulation (Reference) versus the liquid formulation of Luveris in the pre-filled pen (Test) based on the PK parameters AUC0-t and Cmax of serum LH.…
The major objective of the present study is to examine the effect of consuming vitamin E (804 mg) or lipoic acid (600 mg) for 4 weeks on fasting oxyphytosterol concentrations in subjects with impaired glucose tolerance or type 2 diabetes.
This study aims to investigate how serotonin influences social functioning in healthy adults with a first-degree family member diagnosed with MDD. The primary goal is to investigate the effect of an experimental increase in brain serotonin on…
To determine the potential pharmacokinetic interaction between GSE and dextromethorphan in healthy volunteers.
Primary: to assess the safety and tolerability of one oral dose of CB-189,625 at 6 dose levels in healthy male volunteers.Secondary: to determine the plasma pharmacokinetic profile of one oral dose of CB 189,625 at 6 dose levels in healthy…
In this functional Magnetic Resonance Imaging (fMRI) study, the primary objective is to examine the acute effects of intranasal OT administration on emotional- and reward-related brain processes in PTSD patients compared to traumatized healthy…
Primary objective:To show that addition of dead space to low-pressure nCPAP (which is usually not effective but can be relatively well tolerated) makes the therapy effective and diminishes the apnea hypopnea index with >10/hour in patients…
Based on our hypothesis that differential availability of SCFA will have beneficial effects on substrate and energy metabolism, the following objectives will be addressed:In this pilot study we will validate whether rectal administration of SCFA is…
To determine differences in food cue reactivity between lean individuals and individuals with overweight. We will study behavioural (food choice, food intake, mood ratings) as well as physiological parameters (heart rate, skin conductance, saliva…
The aim of this study is therefore to investigate the role of the 5-HT2a receptor in the MDMA-induced effects on social behaviour.
(this text is taken from the protocol, see protocol for the detailed version)The main objective of the study is to gain insight in the underlying mechanism of tinnitus suppression. This objective will be achieved by comparing the suppressive effect…
Primary: To establish the tolerance of camel*s milk and mare*s milk in standardized food provocation tests in patients with double-blind placebo-controlled provocation (DBPCP) proven CMA >=3 years of age. Secondary: To determine the minimum…
The primary objective of the present study is to evaluate the effect of a high soy protein diet on insulin resistance and glycemic control in participants with characteristics of the metabolic syndrome. Secondly, the present study will evaluate…