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Open label, randomized, cross-over study to explore the pharmacokinetics of BAY 1834845 after oral and intravenous dosing, including food effect and absolute bioavailability (Part A), and to investigate the effect of BAY 1834845 on the pharmacokinetics of orally administered methotrexate (Part B) in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent BAY 1834845 is absorbed and eliminated from the body (this is called pharmacokinetics). In both study parts it will also be investigated to what extent BAY 1834845 is…

Pilot study into the biomechanical working mechanisms of a brace that aims to prevent hip dislocation after total hip replacement surgery

What is the influence of the Rebound Hip and Newport 4 hip brace on restricting the movements that are associated with hip dislocation after at total hip replacement.

A Randomised Placebo-Controlled Double-blinded High Cervical Epidural Neurostimulation Trial in patients with Intractable Cervicogenic Headache

The primary objective in this study is to evaluate effectiveness of optimized high cervical epidural neurostimulation against placebo-stimulation in patients with intractable cervicogenic headache in a neurostimulation trial.

Effect of a soft brace on pain, knee stability and activity limitations in patients with knee osteoarthritis

The primary aim of the study is (i) to assess the effect of a soft brace on pain, knee stability and activity limitations. Secondary aims are (ii) to assess the difference in effect of two knee soft braces (i.e., non-tight and tight) on pain and…

Open-label study to compare the bioavailability of an oral tablet of GLPG1972 relative to an oral solution after single-dose intake in healthy subjects and to evaluate the effect of food on the oral tablet.

The purpose of the study is to investigate the absorption, distribution and elimination of GLPG1972 administered as oral solution compared to GLPG1972 administered as oral tablets (this is called bioavailability). Furthermore, the effect of food on…

Injection technique ankle joint

The aim of this study is to investigate the efficacy, accuracy and patient satisfaction of intra-articular injections in the osteo-arthritic ankle joint using the traction device compared to the conventional method of injecting.

Safety and efficacy of vaccination with T cell-dependent and T cell-independent primary and recall antigens in patients with rheumatoid arthritis treated with anti TNF-* antibodies (adalimumab) or anti B cell therapy (Rituximab).

To assess the effect of adalimumab and rituximab on the safety and efficacy of vaccination with T cell-dependent and T cell-independent primary and recall antigens.

Splinting for carpometacarpal osteoarthritis: which splint reduces pain the most?

(1) To analyze differences in pain and function in patients with CMC-1 osteoarthritis after application of a custom made orthosis and an off-the-shelf orthosis (Push brace) (2) To measure compliance and factors influencing compliance with splint…

A pharmacokinetic study to compare the bioavailability between MK-0663 (etoricoxib ) 120 mg Tablets from Two Different Manufacturing Sites (Frosst Iberica, Spain versus Elkton, VA, USA).

The primary objective(s) of this study is:- To determine the relative bioavailability of etoricoxib 120 mg tablets manufactured at Frosst Iberica, Spain and Elkton, VA, USA.

Exploring the mechanism of action of low-dose glucocorticoids: a study of oral versus parenteral glucocorticoids.

Main study: to examine whether low dose GC therapy is more effective via the oral route compared to the parenteral route.Dose finding study (pilot study): to examine which oral GC dose is needed for a noticeable decrease in Erythrocyte Sedimentation…

Data collection to develop data driven algorithms for predicting the right advice at the right time in patients with hip and knee osteoarthritis: a cross-over study

The primary objective of this study is to collect data to develop data-driven models to predict changes in physical functioning over time which will be used within the ArtroseCoach web application.