30 results
3D-vision during robotic PJ and HJ biotissue anastomoses will reduce procedure time and improve surgical performance as compared to 2D-vision.
Appropriate use and prescription of a lower limb prosthesis for people with leg amputation through or above the knee, can increase the efficiency of the integrated care around the leg prosthesis.
we hypothesize that thermal comfort and sensation will stay within similar ranges in both conditions (based on a previous study);
After absorption tamoxifen is metabolized by CYP3A4 and CYP2D6 in several (active) metabolites of which endoxifen is the most important.(11) Tamoxifen, like many anti-cancer drugs, relies on phase II metabolism before they can be excreted from the…
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
To investigate the acute responses occuring in the esophageal mucosa of EoE patients after local allergen provocation
1. Serum potassium in hemodialysis patients (CKD stage 5D) is mainly influenced by alterations in the internal potassium balance. 2. Higher dialysate potassium in CKD-5D increases the potassium erythrocyte concentration as proxy for TBK. 3. The…
In the current study, we will construct utility functions of two opioids, tapentadol and oxycodone, to assess the benefit/harm ratio of these drugs. To that end we will perform a PK PD study in healthy volunteers
1. To investigate different modes of allergen administration to the esophageal wall, by testing the effect on visible mucosal changes2. To investigate which immune cells become activated after allergen provocation 3. To investigate whether the…
The aim of the present study is to examine the interaction (and underlying mechanisms) between hepatic fructose and glucose metabolism in humans. The first objective is to determine the dose-effect relationship between oral fructose and the plasma…
The study focuses on children and young people with IBD from 6-18 years old. These children have lower levels of physical activity and a limited endurance compared to healthy children. Through this research we want to improve the endurance of…
Primary objective1. To compare the Area under the curve (AUC) of endoxifen in patients with breast cancer treated with tamoxifen with and without diclofenac.Secondary objectives1. To compare the Area under the Curve (AUC) of tamoxifen and endoxifen-…
The aim of this randomised crossover trial is to compare the Manometric TMC brace with conventional plaster braces in terms of patient satisfaction, pain, hand function, compliance and patient preference.
The primary objective is to investigate whether Kori-tofu protein affects postprandial blood glucose concentrations, when administered as a part of an ordinary high carbohydrate meal. The secondary objective is to investigate whether Kori-tofu…
We aim to assess the impact of 4-week BG supplementation on blood glucose levels and glucose tolerance in subjects with an impaired fasting glucose or with an impaired glucose tolerance. In addition we will evaluate how BG supplements modulate…
To examine the effect of two different degludec dose adjustments on glucose profiles and the incidence of (nocturnal) hypoglycaemia after oxidative exercise in people with DM1 at elevated risk of hypoglycaemia.
The primary objective of this study is to determine the effect of three different fat blends on underlying mechanistic and immune responses in the circulation. The secondary objectives of this study are: 1) to examine the effects of the three…
The aim of this study is to investigate 1. the extent to which patients who have paresis/non-spastic paralysis of the lower extremity and who are moderately active experience an improvement in the (trunk) balance through the use of a computer-…
This study aims to establish a plasmakinetic profile of GABA from tomatoes in healthy men and compare it to the kinetic profile of GABA from a supplement. In addition, the effects of glutamate (precursor of GABA) on the plasma-time curves of GABA…
The primary objective of this study is to investigate the effects of breads made from well-characterised Bread wheat, Emmer wheat, or Spelt wheat of fully known composition each yeast (study A) or sourdough (study B) fermented on intestinal symptoms…