71 results
Determinination of the added effects of dietary sodium restriction or diuretic use to antihypertensive and antialbuminuric therapy.
We will evaluate the acute effects of GH on, and its relation with, cognition in healthy subjects. The present proposal focuses on the following questions:1. Does an acute rise of plasma GH levels have a (beneficial) effect on cognitive performance…
Primary objective:To assess whether a single day infusion of the GLP-1 RA exenatide, as compared to placebo, reverses GC-induced impairment of glucose metabolism and beta-cell function in healthy males
The main objective is to demonstrate the activation of the efferent inhibitory cortico-olivocochlear pathway with otoacoustic emission of the ear contralateral to the side of stimulation with TMS. We expect the amplitude to decrease after TMS of the…
Analyze the protective effect of levocetirizine (LEV), through the direct antagonism of airway H1 receptors and the inhibition of the release or production of other inflammatory mediators, against exercise induced airway obstruction.
Project 1: To investigate the neuroanatoimical correlates of attentional processing bias in nicotine addicts, using fMRI.Project 2: To examine whether attentional biases are dependent on dopaminergic transmission in the mesolimbic system using…
To investigate if the GH-promoting effect of gelatine- protein is present in non-overweight and overweight elderly people.
The aim of this research is to determine the effect of glucose in the small intestine on the secretion of hormones, appetite related feelings and food intake, and whether these effects differ between time of day (morning vs evening) and segment of…
To determine the safety and tolerability of P1201-07 administered as single ascending oral doses in overweight or obese but otherwise healthy subjects.
This study is being performed to document the effects of the new compound AZD7325 on brain functions and to investigate whether it has fewer side-effects compared lorazepam.
Primary:* To investigate the safety and tolerability of the co-administration of GSK598809 at175 mg and ethanol in healthy volunteers.* To examine the potential pharmacokinetic interactions between GSK598809administered at 175mg and ethanol in…
To evaluate and implement the cutaneous electrical stimulation pain model at the Kendle Clinical Pharmacology Unit.To investigate whether these human experimental pain models can discriminate the analgesic effects of a single oral dose of Tramadol…
to assess the tolerability and safety after single oral ascending doses of SAR501788 in healthy young male subjects (Part 1)to assess the tolerability and safety after repeated oral ascending doses of SAR501788 in healthy young male subjects (Part 3…
To assess the effect of cocoa-containing drinks either rich in flavanols or rich in flavanols and theobromine on blood pressure in untreated subjects with high normal blood pressure (prehypertension) or grade I hypertension as measured by 24-hours…
Primary Objective:* To investigate the effects of THC on fMRI activation patterns in healthy volunteersSecondary objective:* To assess the feasibility of pharmacokinetic/pharmacodynamic (PK/PD)-analyses for THC-induced fMRI-activation patterns* To…
We hypothesize that local AMPs expression in the airways of patients with asthma is decreased as a result of allergic inflammation. Furthermore, we hypothesize that local AMP expression can partly be restored by vitamin D substitution therapy. We…
• Identify regional specificity of dopaminergic drug effects, i.e. the distinct behavioural roles of dopamine in the striatum and dopamine in the prefrontal cortex.• Identify receptor specificity of dopaminergic drug effects, i.e. the distinct…
The goal of this research is to see whether offering fluoride three times a day enhances the remineralisation of an early cariouslesion more than fluoride twice a day.
To further study effects of a single administration of cortisol, compared to placebo, on different aspects of attention and other cognitive processing of emotionally relevant information in healthy young men. This should provide new information on…