51 results
To study the feasibility and safety of permissive lung–protective ventilation in adult critically ill patients receiving invasive ventilation for acute hypoxemic respiratory failure, and to inform the design of a future randomized clinical trial in…
This study aims to compare outcomes between ring augmented RYGB (RaRYGB) using the MiniMizer and standard RYGB without a ring.
The objective of the proposed study is to assess the effect of a combined lifestyle intervention for patients with cancer, who suffer from the consequences of cancer and its treatment, on Health-Related Quality of Life (HRQoL)
This study aims to evaluate and compare the long-term outcomes of tissue-level and bone-level single implants in the posterior region of the mandible or maxilla in patients with adequate bone for implant placement, with or without prior bone…
The ultimate goal is to investigate whether aVNS can enhance cortical plasticity and improve functional outcomes during intensive rehabilitation programs in children with cerebral palsy. First, we aim to establish the extent of cortical plasticity…
Primary objectives:• To characterize the central inflammatory response to IV LPS by measuring biomarkers in CSF• To characterize the systemic inflammatory response to IV LPS by measuring biomarkers in blood • Characterize CSF/Blood ratios for each…
The primary aim of this study is to investigate the effects on PA, sleep, stress, health and QoL of a tailored eHealth intervention for cancer patients when embedded in oncological care. Additional aims are to gain insight into the cost-…
Primary Objective: To study the association between muscle characteristics (contractile, morphological,biochemical, and histological) and the response to high- and low-load exercise training on muscle strength in patients with rheumatoid arthritis (…
Primary: To compare the efficacy of epigenome-guided treatment selection to usual standard of care (SOC) treatment selection for inducing clinical remission and endoscopic response at Week 26 in participants with active CD.Secondary:-To explore the…
To investigate the effect of nutritional prehabilitation on adverse events in patients with locoregionally advanced head and neck cancer, with low to medium risk of malnutrition and with radiological sarcopenia. To evaluate its effect on patient-…
The primary objective is feasibility of a prospective randomized trial, to investigate whether a more restrictive RBC transfusion strategy of 5.0 g/dL (3.1 mmol/L) is non-inferior compared to the current transfusion threshold of 7.0 g/dL (4.3mmol/L…
To evaluate the contribution in terms of information provision and patients* perspectives of ICU-VR to prepare lung transplant patients for their future ICU admission
The primary objective is to evaluate the effectiveness of dietary nitrate in reducing muscle atrophy induced by bedrest. Secondary objectives include assessing its impact on insulin resistance, muscle strength, and cardiovascular function.…
To demonstrate the clinical efficacy and safety profile of canaloplasty utilizing the iTrackTM Advance canaloplasty device performed via an ab-interno surgical technique achieves:1. Enhanced IOP reduction at 12 months due to the techniques ability…
The main objective of this study is to assess the feasibility, safety and (cost-)effectiveness of the HOME-ART intervention in comparison to regular hospital admission in patients with CA-ARTI.
The REPLACE study aims to determine whether not changing the catheter (catheter retained) for catheter-associated urinary tract infections (CAUTI)affects the recurrence-risk of CAUTI.
In this pilot study, we aim to assess practical feasibility, technical feasibility and safety of a computational approach for programming newly implanted STN-DBS patients with PD. This computational approach will be based on patient-specific sweet…
To evaluate if balloon pulmonary angioplasty (BPA) is non-inferior to pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are eligible for both treatments.
1) Patient reported function, satisfaction and quality of life 2) Medical costs and productivity loss. 3) Injury-related amputation of the lower extremity; 3) Unplanned reoperations to manage infection, flap compromise, or flap loss; 4) Days in the…
The primary aim of the cluster Randomized Controlled Trial (cRCT) is to evaluate the effectiveness of the Girls United prevention program on self- and parent-reported mental health outcomes in a sample of max 320 young adolescent girls aged 10 to 12…