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Clinical evaluation of Remote monitoring with dirEct Alerts* to reduCe Time from event to clinical decision

St. Jude Medical developed the Merlin.net* Patient Care Network (Merlin.net* PCN) to augment or replace routine scheduled in-clinic visits. This investigation is designed with the hypothesis that detection of events (system integrity and diagnostic…

Evaluation of an intervention to decrease the need for recovery in office employees by increasing daily physical activity and relaxation at work.

The aim of this study is to evaluate an intervention program consisting of group motivational interviewing (GMI), supported by a social media platform, and/or environmental modifications, to decrease the need for recovery in office employees by…

A Randomized, Multicenter, Double-Blind, Parallel, Placebo-Controlled Study of the Effects of JNJ 28431754 on Cardiovascular Outcomes in Adult Subjects With Type 2 Diabetes Mellitus

In subjects with T2DM, with inadequate glycemic control, who have a history or high risk of CV disease:Primary Objectives*to assess the effect of canagliflozin plus standard of care relative to placebo plus standard of care on CV risk as measured by…

The effectiveness and evaluation of the online 'Kanker Herstel Hulp' intervention in cancer survivors.

The project primarily aims to study short (3 and 6 months) and long term (12 months) health related effects of the 'Kanker Nazorg Wijzer' on survivors' psychosocial distress and quality of life (QoL). Furthermore, process aspects of…

Effects of a nurse coordinated program of lifestyle improvement aimed at reducing the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.;RESPONSE2: (Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists 2)

Primary Objective: To determine the effectiveness of a comprehensive lifestyle intervention program aimed at reducing the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.Secondary Objective:…

Prophylactic infusion of CD4 positive donor lymphocytes early after T-cell depleted allogeneic stem cell transplantation in patients with an unrelated donor

In this phase II study, the toxicity and treatment effects of early donor derived CD4+ lymphocyte infusion, three months after allo-SCT, will be evaluated

Experimental human malaria infection after immunization with Plasmodium falciparum sporozoites under chloroquine prophylaxis.

Primary objective: To investigate whether CPS immunization confers protection to a blood stage challenge.Secondary objectives: • To study and compare parasitemia after challenge between study groups• To analyze and compare the immune responses…

Cost-effectiveness of a lifestyle intervention on health and sustainable employability among workers of 40 years and older with high physical work demands: a randomized controlled trial

- to evaluate (cost-) effectiveness of a personalized health intervention among workers of 40 years and older with high physical work demands to contribute to a reduction in CVD and sustainable employability.

A study of more time-efficient and cost-effective pre-exposure rabies vaccination schedules to secure timely adequate protection prior to military deployment

1. To reduce the time required for pre-exposure rabies vaccination of military personnel2. To reduce costs of pre-exposure rabies vaccination of military personnel 3. To obtain a non-inferior immune response to a shortened, low-dosed scheme compared…

A Three-Part, Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Sequential Adaptive, Phase II Study to Evaluate the Safety, Tolerability and Efficacy of OPN305, a Humanised Monoclonal Antibody that Blocks Toll-Like Receptor 2, in Renal Transplant Patients at High Risk of Delayed Graft Function

Primary Objectives:*Phase 0: To determine the receptor occupancy of OPN-305 1.5mg/kg in patients receiving an ECD, DCD or SCD(CIT>18h) kidney transplantation and to verify the doses of OPN-305 to be used in Part A of the study.*Part A: to…

After the Health Check in vulnerable groups: an individually tailored self regulation intervention led by Community Health Workers.

The overall objective of this study is to increase the uptake and maintenance of healthy behaviors among adults from non-Western immigrant populations who are identified as having a high risk of cardiometabolic disease after completing a health…

Epidural anesthesia for OPCAB, a randomized comparison between general anesthesia alone or general anesthesia combined with high thoracic epidural anesthesia for off pump CABG

In the present study we will determine the effect of sympathetic blockade by TEA on major outcome parameters after off-pump CABG.

Pre-operative treatment with Erythropoietin and iron supplement for prevention of perioperative blood transfusion in cardiac surgery

Primary objective: To determine the reduction of number of patients who receive blood transfusion perioperatively in the group pre-treated with erythropoietin and iron supplement compared to the control patients.

(Cost-) effectiveness of a Multi-Component Intervention for adults with epilepsy: a Dutch randomized controlled trial

The overall objective is to assess the (cost-) effectiveness of MCI (self-management/education program & e-health) aiming to improve self-efficacy and adherence in people of with epilepsy compared to care as usual (CAU).The study consist of…

Remote Ischemic Conditioning in Renal Transplantation - Effect on Immediate and Extended Kidney Graft Function

Investigate wether rIC, a simple, non-invasive procedure which could be easily implemented in clinical care, can improve immediate and long term kidney graft function after transplantation from deceased donors

Effect of Health games on Cognitive Function in Parkinson*s Disease

The main aim of this phase-II-proof-of-principle study is to test whether the health game AquaSnap offers improvement of cognitive impairment in PD patients with mild cognitive impairment, using an RCT. The long-term ambition is to test whether the…

A Randomized Clinical Trial of Cutaneous Xylocaine Spray to Reduce Intravenous Cannulation Pain in Adults.

Objective: Adequate analgesia during intravenous cannulation.Hypothesis: Xylocaine spray for the placement of an infusion decreases the pain score with two or more points in comparison to placebo spray.Studie questions:Primary: Has xylocaine spray…

Deep and slow breathing in postsurgical abdominal pain management: an explorative study

To investigate whether deep and slow breathing exercises can reduce pain induced by mobilizing from bed to chair after major abdominal surgery, compared to a reading task.

Employing dynamic kinetic responses to demonstrate the effectiveness of dietary intervention: A challenge-based study using a low-glycaemic load diet

Primary objective: To assess the impact of a low glycaemic load (GL) diet as compared to a *Western* diet on metabolic flexibility (the change in RQ) upon a hyperinsulinemic euglycemic clamp. Secondary objectives: 1) To assess the impact of low GL…

From expecting to experiencing: The role of parenting cognitions in the transition to parenthood

Study 1 is aimed to describe normative trajectories of parenting efficacy from pregnancy to early parenthood. Study 2 is focused on the question whether mental representations of attachment are protective in the context of parenting stress and its…