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Pressure Microcatheter vs Pressure Wire for Clinical Decision Making and PCI optimization

The primary objective of the study is to assess the safety and efficacy of a pressure microcatheter guided treatment decision and PCI optimization compared to a pressure wire based strategy.

BCG-induced epigenetic modifications in the NEXT generation

To study the possible epigenetic modifications in sperm cells after BCG vaccination

The importance of non-essential amino acids for maintaining skeletal muscle protein synthesis rates in healthy young men

The purpose of this study is to determine if a diet lacking NEAA, with or without being replaced by additional EAA, influences skeletal muscle protein synthesis rates and whole-body metabolism in healthy young men.

EFFECTS AND UNDERLYING MECHANISMS OF PHOTOBIOMODULATION (PBM) ON HEALTH AND WELL-BEING

To follow up on the previous study on PBM effects on well-being by prospectively assessing mood, drowsiness and depression as well as energy/tiredness/tension/calmness, and sleep parameters, and on health by prospectively assessing resting heart…

A randomized, placebo-controlled, double blind trial to study the effects of Etidronate on ectopic CALCIfication in FAhr*s Disease or syndrome.

This study has been transitioned to CTIS with ID 2024-512300-19-00 check the CTIS register for the current data. The objective is to determine whether etidronate can halt or attenuate disease progression in patients with Fahr*s disease or syndrome.

A cognitive reappraisal intervention for the reduction of anxiety in eating disorders: an experimental study with exposure in virtual reality

The current study investigates the effectiveness of an intervention that focusses on the adaptive emotion regulation strategy cognitive reappraisal for people with EDs in the reduction of anxiety. This intervention will be compared to a control task…

Peri-operative slow paced breathing - a non-invasive technique to reduce anxiety in breast cancer surgery patients

This study aims to examine the effects of guided slow paced breathing performed at induction of anesthesia in patients undergoing surgery for breast cancer on anxiety, scored by Spielberger's State-Trait Anxiety Inventory, State scale (STAI-S…

A PHASE II, MULTICENTER, RANDOMIZED, DOUBLE-BLIND STUDY OF RO7247669 COMBINED WITH NAB-PACLITAXEL COMPARED WITH PEMBROLIZUMAB COMBINED WITH NAB-PACLITAXEL IN PARTICIPANTS WITH PREVIOUSLY UNTREATED, PD-L1*POSITIVE, LOCALLY-ADVANCED UNRESECTABLE OR METASTATIC TRIPLE-NEGATIVE BREAST CANCER

Primary Objective: This study will evaluate the efficacy, safety, and pharmacokinetics of RO7247669 plus nab-paclitaxel compared with pembrolizumab plus nab-paclitaxel in patients with previously untreated, locally advanced, unresectable or…

Effectiveness of computerized training of attention and working memory in Post COVID-19 patients with cognitive complaints

Primary Objective: The aim of this study is to research the effect of a computerized cognitive rehabilitation program (RehaCom) in post COVID-19 patients with cognitive complaints on their sustained and divided attention and their working memory.…

A randomized phase II trial of docetaxel or cabazitaxel with or without darolutamide in men with metastatic castration-resistant prostate cancer.

This study has been transitioned to CTIS with ID 2024-516939-28-00 check the CTIS register for the current data. To compare progression free survival (PFS) between treatment with docetaxel or cabazitaxel and darolutamide versus treatment with…

The GATE trial: Endoscopic sutured Gastroplasty in Type 2 diabetic, obese patients using the Endomina device - a randomized controlled trial, and its effect on incretin hormones

The primary objective of this study is to evaluate the efficacy of endoscopic sutured gastroplasty with the endomina device (EndoTools Therapeutics S.A.) on glycemic control (reduction in insulin dose), in obese insulin treated type 2 diabetes…

Effectiveness of early use of the mechanical insufflation- exsufflation compared to air stacking to reduce respiratory tract infections in patients with Duchenne muscular dystrophy.

The aim of this study is to determine whether MI-E leads to a lower number of RTIs as compared to AS combined with MAC in DMD patients with a PECF< 270 l/min over a period of two years.

The effectiveness and cost-effectiveness of Occupational Therapy at Home E-Rehabilitation (OTHER) for persons post-stroke

To determine the (cost)effectiveness of OTHER (Occupational Therapy at Home E-Rehabilitation), as compared to usual OT, on improving the self-perceived performance in daily activities of community-dwelling older persons post-stroke over a 24-week…

Duration Of Music Interventions aNd pAiN Tolerance in healthy individuals

The main objective is to investigate the effect of different durations of music interventions on pain endurance. Secondary objectives are to investigate the effects of music duration on heart rate variability and subjective measurements of emotions…

Intercostal nerve cryoablation versus thoracic epidural analgesia for minimal invasive Nuss repair of pectus excavatum: A protocol for a randomized clinical trial (ICE trial)

Primary objective of the current study is to determine the impact of intercostal nerve cryoablation on postoperative length of hospital stay compared to standard pain management of pectus excavatum patients treated with the minimal invasive Nuss…

Lower urinary tract symptoms in Parkinson's disease effectiveness of pelvic floor muscle exercises and electrical stimulation

Objective: To study the effectiveness of pelvic physical therapy and ES in patients with PD suffering from LUTS. Which are the most effective parameters for ES. Intervention: Intervention: 8 treatment sessions of 30 minutes pelvic physical therapy…

Postponing cognitive decline and preventing early unemployment in patients with multiple sclerosis - strengthening the brain and mind (part of the Don't be late! study)

(1) To compare the efficacy of two innovative preventative interventions with a control intervention in improving quality of life, cognition, work participation and productivity, brain plasticity and resilience, (2) to gain insight into the…

A Pilot, Multicenter, Randomized, Non Comparative, Double-Blind Study of Phage Therapy in Patients with Hip or Knee Prosthetic Joint Infection due to Staphylococcus aureus Treated with DAIR and Antibiotic Therapy

Considering the paucity and the variability of data regarding the clinical control of infection in patients presenting a prosthesis Joint Infection (PJI) later than 1 month after the arthroplasty and treated with DAIR + suppressive antibiotics…

Strong Teens and Resilient Minds: School-based depression and suicide prevention in adolescents attending special schools

The aim of the study is to establish depression and suicide prevention reaching students who attend special education.The primary goal is to evaluate the effectiveness on depressive symptoms of a screening and prevention program for adolescents who…

Antibiotics vs antibiotics and Surgical ThERapy for Infective endocarditis

To test whether valve surgery plus medical therapy is superior to medical therapy alone for treatment of endocarditis.