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Optimizing exposure therapy for Posttraumatic Stress Disorder - a single case experimental design

The current project investigates whether ILT-based exposure (strategies and techniques based on insights from ILT) leads to symptom reduction and is an acceptable treatment (for both patients and therapists). Additionally, we will examine whether…

Sterile versus Aseptic treatment in Dento-Alveolar Surgery*

The main objective is whether the standard use of non-sterile gloves and/or drapes can be a safe and a good alternative in dento-alveolar surgery. The second objective is to determine whether the use of non-sterile gloves or covering materials is…

The effect of preventive oxygen therapy on sleep disordered breathing and sleep architecture during the first postoperative night after bariatric surgery

The primary objective of this study is to assess the effect of preventive oxygen therapy on sleep disordered breathing during the first postoperative night after bariatric surgery. The secondary objective of this study is to observe the effect of…

Peripheral Nerve Stimulation (PNS) to optimize military performance during and after sleep deprivation

The main objective of the proposed study is to investigate the effect of ctVNS as a means to counteract the effects of SD on cognitive performance during and after SD. This will be tested using both well-controlled, established cognitive desktop…

User experience study of digital tools to collect data on wellbeing and side effects in cancer patients

This is a feasibility designed to investigate the feasibility of collecting QoL information from patients via digital tools. By feasibility, we mean the assessment of the uptake of the tool, the compliance to schedule and the quality of the data…

An Open-Label, 2-Arm, Multicenter, Randomized Phase 3 Study To Evaluate The Efficacy And Safety of Elranatamab (PF-06863135) + Daratumumab + Lenalidomide Versus Daratumumab + Lenalidomide + Dexamethasone in Transplant-Ineligible Participants With Newly-Diagnosed Multiple Myeloma

This study has been transitioned to CTIS with ID 2024-514139-50-00 check the CTIS register for the current data. Part 1PrimaryTo assess dose limiting toxicities (DLTs) of EDR to select an RP3D for the combination to be used in Part 2 of this study.…

A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PHASE I STUDY TO ASSESS THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF SINGLE AND MULTIPLE ASCENDING DOSES OF THN391 IN HEALTHY SUBJECTS

This study has been transitioned to CTIS with ID 2024-517955-10-00 check the CTIS register for the current data. In this study we will investigate how safe the new compound THN391 is and how well it is tolerated when it is used by healthy subjects.…

A Phase IIa, randomised, double-blind, placebo-controlled trial to evaluate the safety, efficacy, pharmacokinetics and pharmacodynamics of BI 706321 orally administered for 12 weeks in patients with Crohn`s Disease (CD) receiving ustekinumab induction treatment

The main objectives Investigate a first signal of efficacy, safety and tolerability of BI 706321 in combination with ustekinumab treatment compared to placebo with ustekinumab treatment in patients with moderately to severely active CD at 12 weeks.…

The therapeutical efficacy of senolytic drugs in the treatment of non-alcoholic fatty liver disease with fibrosis - the truth study

This study has been transitioned to CTIS with ID 2024-517593-21-00 check the CTIS register for the current data. To examine the effect of oral dasatinib plus quercetin on liver fibrosis as assessed by histology in individuals with biopsy-proven…

TRUE-GRIT: Reducing cognitive impairment in glioma with repetitive transcranial magnetic stimulation and cognitive strategy training

To investigate the feasibility of a combination therapy (consisting of individualized rTMS and cognitive strategy training) and study measurements in patients with a primary brain tumor during stable disease. The study is considered feasible when 80…

The Vold-study: The effect of a 12-week self-composed vegan diet with or without concurrent resistance exercise on thigh muscle volume in older adults

Primary: To assess the effects of a 12-week self-composed vegan diet in comparison to an omnivorous diet on thigh muscle volume (TMV) in community-dwelling older adults. And to assess the effect of a 12-week self-composed vegan diet combined with…

Early PReserved SPONtaneous breathing activity in mechanically ventilated patients with acute respiratory distress syndrome - The PReSPON Randomized Controlled Trial

To evaluate the efficacy and safety of preserved spontaneous breathing activity in the early phase of moderate to severe ARDS.

The effects of branch pulmonary artery stenting in d-TGA, ToF and TA: a randomized control trial

The primary study objective is to identify the effects of percutaneous interventions for branch PA stenosis on exercise capacity in patients with d-TGA, ToF and TA. The secondary objectives are 1) to assess the effects of percutaneous interventions…

A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients with Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy

This study has been transitioned to CTIS with ID 2024-510742-13-00 check the CTIS register for the current data. The primary objective is to compare the objective response rate (ORR) assessed per Response Assessment in Neuro Oncology for low-grade…

Virtual Pain Care; The effectiveness of Virtual Reality Therapy on reducing pain, and anxiety during complex wound care procedures in adults

To assess whether the use of Virtual Reality Therapy can reduce pain, and anxiety than without Virtual Reality Therapy in patients undergoing complex wound care procedures.

Reviving Early Diagnosis of Cardiovascular Disease in the Utrecht Health Project

RED-LRGP: To investigate the yield of a screen-like early diagnosis strategy as compared to usual primary care in terms of the number of newly diagnosed coronary artery disease, atrial fibrillation, and heart failure in community people aged 50-80…

Transoral robot surgery of the tongue base vs. Continuous positive airway pressure or mandibular advancement device as a treatment for moderate to severe obstructive sleep apnea.

The primary objective of this study is to objectify the efficacy of TORS compared to CPAP and MAD. Secondary objectives:To determine long term outcomes of TORS compared to CPAP or MAD.To compare functional sleep outcomes in TORS and CPAP/MAD…

A double-blind, randomized, placebo-controlled, phase 2a study to evaluate the safety, tolerability, and pharmacodynamic (PD) effects of two infusions of escalating doses of TPM502 in adults diagnosed with celiac disease (CeD)

Main objective:To evaluate the safety and tolerability of two i.v. infusions of escalating doses of TPM502 in CeD patients.Secondary objectives:• To identify PD effects consistent with the induction of antigen-specific immune tolerance following the…

Effectiveness of focal therapy in men with prostate cancer (ENFORCE)

We hypothesize that a significant proportion of the patients will benefit more from focal therapy as compared to usual care in terms of morbidity and quality of life, without compromising oncological effectiveness. Primary objective: To study the…

The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients with Complex Iliac Occlusive Disease

The primary objective of this trial is to demonstrate the superiority of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis for primary patency when compared to bare metal stenting for the treatment of patients with complex iliac occlusive…