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Catalyst Trial: Clinical trial of atrial fibrillation patients comparing left atrial appendage occlusion therapy to non-vitamin K antagonist oral anticoagulants

The objective of this trial is to evaluate the safety and effectiveness of the Amulet device compared to NOAC therapy in patients with non-valvular AF at increased risk for ischemic stroke and who are recommended for long-term NOAC therapy.

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Arm, Multicenter Study Evaluating the Efficacy and Safety of Pridopidine in Patients with Early Stage of Huntington Disease

The purpose of this Phase 3 study is to further evaluate the effect of pridopidine 45*mg BID on functional capacity, as well as motor and behavioral features of HD in early-stage participants (TFC*713).

DIrect or Subacute COronary angiography in out-of-hospital cardiac arrest - a
prospective, randomized study

To investigate whether a strategy of immediate coronary angiography (within 120 minutes) results in improved 30-day survival of out-of-hospital cardiac arrest patients without ST elevation on the ECG, when compared to no immediate coronary…

A RANDOMIZED TRIAL COMPARING RADICAL HYSTERECTOMY AND PELVIC
NODE DISSECTION VS SIMPLE HYSTERECTOMY AND PELVIC NODE DISSECTION
IN PATIENTS WITH LOW RISK EARLY STAGE CERVICAL CANCER

Primary objective:To evaluate whether treatment with simple hysterectomy and pelvic node dissection is non-inferior to treatment with radical hysterectomy and pelvic node dissection in terms of pelvic relapse-free survival.Secondary objectives:To…

the BREAST trial (the Breast Reconstruction with External pre-expansion and Autologous fat transfer vs Standard Therapy trial)

This study aims to determine the effectiveness of a new breast reconstruction technique: Autologous fat transfer (AFT). This technique combines the advantages of using the patients* own tissue (fat cells), while being minimally invasive compared to…

A multi-center randomized controlled study of primary prevention of esophageal variceal bleeding in cirrhotic patients treated with HVPG-guided beta- blocker therapy or standard heart rate-guided beta-blocker therapy.

To determine cost-effectiveness of hepatic venous pressure gradient (HVPG)-guided nonselective beta-blocker therapy as compared to standard heart rate-guided beta-blocker therapy in the primary prevention of esophageal variceal bleeding in cirrhotic…

Driving pressure during general anesthesia for open abdominal surgery - a randomized controlled trial

The overall objective of this RCT is to determine the effectiveness and long-term outcome of an high PEEP strategy, aiming at preventing atelectasis, but avoiding an increase in driving pressure, during intraoperative ventilation. Specifically, this…

A randomized, double-blinded placebo controlled trial to evaluate the efficacy of a multivitamin and mineral supplement to prevent infections in patients with inflammatory bowel disease.

To evaluate the efficacy of an over the counter multivitamin and mineral supplement, compared with an identically in appearance placebo on the incidence of infections in patients with inflammatory bowel disease with a high risk for infection.

Pilot study on robot-assisted microsurgical lymphatico-venular anastomosis

This pilot study assesses the performance of a robot-assisted microsurgery. Lympho-venular anastomosis(LVA) is the most difficult procedure in microsurgery at this moment. This LVA technique is applied to treat for example breast cancer related…

Improving therapeutic ratio with hypofractionated stereotactic radiotherapy for brain metastases.

To determine if the incidence of adverse local events (local failure or radionecrosis) can be reduced with more than 20% using fSRT versus SRT in one or three fractions.

Plant stanol esters in the prevention of clinical symptoms related to asthma: the PLANTASTIC trial

The primary objective of this study is to demonstrate clinical benefits of prolonged consumption of plant stanols (delivered via plant stanol esters) in asthma patients. The secondary objectives are to evaluate the mechanisms via which plant stanols…

Long-term effects of a potato-based food pattern vs a rice / pasta-based food pattern on fasting & postprandial cardiometabolic health; The LoPoCardio - trial

The objective is to evaluate the effects of longer-term consumption of diets rich in boiled potatoes versus those rich in rice or pasta on established cardiovascular risk parameters.