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A randomised controlled trial of fMRI-neurofeedback in depression

Primary Objective: To determine whether NFE + standard care is superior to standard care alone in the treatment of depression. Secondary Objective(s): To assess correlations between NFE success and brain activation / clinical changes; to assess…

Multicenter Randomized CLinical trial of endovascular treatment for acute ischemic stroke in the Netherlands. The effect of periprocedural MEDication: heparin, antiplatelet agents, both or neither.

To assess the effect of acetylsalicylic acid (ASA) and unfractionated heparin, alone, or in combination, in patients with AIS, who undergo IAT for a confirmed intracranial anterior circulation occlusion.

Improving patient care through early and objective detection of delirium for geriatric trauma patients in a trauma geriatric center

To quantify the impact of the use of DeltaScan on patient outcome (duration of admission) in patients with high risk of delirium compared to the currently used delirium screening tools.

GAG-therapy Efficacy Trial Solution for Bladder pain syndrome/ Interstitial cystitis

Main objective is to determine short and long term efficacy of GAG therapy (bladder instillations) for people with BPS-IC H+ as compared to placebo treatment on dominant symptoms such as pain. Secondary objectives are to determine the 1) cost-…

A prospective, multicenter, randomized, parallel-group controlled trial to compare conservative versus surgical treatment of foot drop in peroneal nerve entrapment.

The primary research question of the trial is to assess whether foot drop, caused by peroneal nerve entrapment in adult patients* recovers better within 9 months after decompressive surgery compared to prolonged standard conservative treatment. *…

The Diabetes Body Project: Multi-site trial of a virtually delivered eating disorder prevention program for young females with type 1 diabetes

We aim to investigate the efficacy of a novel eating disorder prevention program, the Diabetes Body Project, specifically targeting young females T1D. Firstly, we will test the hypothesis that Diabetes Body Project will produce significantly greater…

Hypnotherapy through self-exercises in children with functional abdominal pain
in primary care

To determine the (cost)-effectiveness of home-based hypnotherapy by self-exercises added to usual care (UC) of general practitioners (GPs) compared with UC of GPs alone in children with FAP or IBS.

A Multi-center, Double-Blind, Randomized, Two-Arm, Parallel-Group, Placebo Controlled Basket Study to Assess the Safety of ELGN-2112 in Populations of Interest

Primary objective: To compare the safety of treatment with ELGN-2112 to placebo in preterm infants born less than 26 weeks GA and IUGR infants<3rd percentile * born at 26-32 weeks GA. * According to Fenton preterm growth chart. Secondary…

Impact of galacto-oligosaccharides on the intestinal microbial composition and -activity: a proof of concept study

We would like to investigate whether GOS benefically alters the microbiota composition and -activity of the colon (not only faeces as done previously). This has not been done before by performing colonoscopies in a physiological condition and…

Tailoring Limb length based on total small bowel length in omega-loop gastric bypass

To investigate whether adjusting the length of the BP-limb of the OAGB based on measured total small bowel length leads to more weight loss, resolution of co-morbidities with less development of micronutrient deficiencies and bowel movements…

Primary care decision rule for chest pain using the Marburg heart score rule and troponin point of care test

To determine the effectiveness of a decision rule compared to the usual care of GP*s for patients presenting with non-traumatic chest pain in primary care.

A randomized trial to investigate the reset of humoral autoimmunity by combining belimumab with rituximab in severe systemic lupus erythematosus

The primary objective is to assess whether combination treatment BLM+RTX will lead to reduced treatment failure and the improvement of pivotal, SLE-specific autoimmune phenomena compared SLE patients treated with standard of care.

A Phase 3 Study Comparing Pomalidomide and Dexamethasone With or Without Daratumumab in Subjects With Relapsed or Refractory Multiple Myeloma Who Have Received at Least One Prior Line of Therapy With Both Lenalidomide and a Proteasome Inhibitor.
The APOLLO Study

The purpose of this study is to evaluate the effects of the addition of daratumumab to pomalidomide and dexamethasone in subjects with relapsed or refractory MM.1. Primary objectiveThe primary objective of this study is to compare PFS between…

Using a complex carbohydrate mixture added to a high-protein DIet to STeer fermentation to improve metabolic, gut and brain heALth

Primary Objective: The main goal of this study is to provide evidence that steering saccharolytic/proteolytic fermentation by a specific indigestible fibre mixture supplemented against the background of a high-protein diet optimizes beneficial and…

A Multi-center, Double-Blind, Randomized, Two-Arm, Parallel-Group, Placebo Controlled Study to Assess the Efficacy and Safety of ELGN-2112 on Intestinal Malabsorption in Preterm Infants

Primary objective: To assess the efficacy of treatment with ELGN-2112 as compared to placebo on intestinal malabsorption in preterm infants as measured by the time to full enteral feeding. Defined as first day of reaching three consecutive days of…

Postponing breakfast in patients using levothyroxine: old-fashioned?

Primary Objective:To investigate whether there is a difference in the number of participants that will reach optimal LT4 supplementation (i.e. stability of TSH levels and symptoms) in the breakfast group compared to the fasting group.Secondary…

The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers in ageing

The primary objective of this study is divided into two steps:Step 1. To investigate the effect of a 26-week (around 6 months) multidomain lifestyle intervention on brain function (working memory, cerebral perfusion) and peripheral immunometabolic…

Treatment of chronic diabetic foot ulcers with Extracorporeal Shock Wave Therapy (ESWT) - a double-blind randomized controlled trial

To improve the healing rate and decrease wound surface area (WSA) of chronic diabetic foot ulcers using ESWT in combination with standard care. Furthermore, this study will investigate the long-term effects of ESWT on ulcer recurrence.

A randomised, double-blind, placebo-controlled, parallel group, dose-finding study evaluating efficacy, safety and tolerability of BI 1291583 qd over at least 24 weeks in patients with bronchiectasis (Airleaf*)

The primary objective of the trial is to assess a non-flat dose-response curve and to evaluate the dose-response relationship for 3 oral dose regimens of BI 1291583 versus placebo, on the primary endpoint, time to first pulmonary exacerbation up to…

Effect of 4 weeks of oral D. piger on safety, pharmacokinetics and ethanol metabolism in overweight individuals (2023)

To assses safety, gut engraftment and effects on sugar- and alcohol metabolism of d. piger in individuals with increased waist circumference.