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OUTER SPACE-2: a randomised study on inhaler treatment adherence using a smart spacer in adults with asthma

Primary objective:To assess the overall feasibility of undertaking a definitive randomized controlled trial on the effects of tailored inhaler education by the GP/nurse supported by a smart spacer, in primary care treated adults with asthma.…

Personalized microbial substrates to prevent type 2 diabetes

In this project we intends to study the therapeutic potential of a personalized fibre mixture in individuals at high risk of developing T2DM, and aims to address the following key objectives: 1. To investigate whether a mixture of fermentable…

A randomized prospective clinical trial comparing OsteoActivator-P coated membranes vs Collagen Membrane-P uncoated for accelerated localized alveolar ridge preservation.

Collagen barrier membranes are widely used for ridge preservation applications. Once an extraction socket is filled with a bone filler and covered by a collagen membrane, guided bone regeneration (GBR) is observed due to the barrier function of the…

Fecal microbiota transplantation for improved Fructose catabolism and Insulin sensiTivity In patients with metabolic syndrome : the FFIT study

We would like to investigate if use of donor FMT enriched desulfovibrio bacterial strains has a beneficial effect on gut microbiota diversity and subsequent improvement of (diet derived) fructose catabolism and insulin sensitivity in patients with…

Improving patient care through early and objective detection of delirium for geriatric trauma patients in a trauma geriatric center

To quantify the impact of the use of DeltaScan on patient outcome (duration of admission) in patients with high risk of delirium compared to the currently used delirium screening tools.

GAG-therapy Efficacy Trial Solution for Bladder pain syndrome/ Interstitial cystitis

Main objective is to determine short and long term efficacy of GAG therapy (bladder instillations) for people with BPS-IC H+ as compared to placebo treatment on dominant symptoms such as pain. Secondary objectives are to determine the 1) cost-…

A prospective, multicenter, randomized, parallel-group controlled trial to compare conservative versus surgical treatment of foot drop in peroneal nerve entrapment.

The primary research question of the trial is to assess whether foot drop, caused by peroneal nerve entrapment in adult patients* recovers better within 9 months after decompressive surgery compared to prolonged standard conservative treatment. *…

Primary care decision rule for chest pain using the Marburg heart score rule and troponin point of care test

To determine the effectiveness of a decision rule compared to the usual care of GP*s for patients presenting with non-traumatic chest pain in primary care.

The effects of a multidomain lifestyle intervention on brain functioning and its relation with immunometabolic markers in ageing

The primary objective of this study is divided into two steps:Step 1. To investigate the effect of a 26-week (around 6 months) multidomain lifestyle intervention on brain function (working memory, cerebral perfusion) and peripheral immunometabolic…

A randomised, double-blind, placebo-controlled, parallel group, dose-finding study evaluating efficacy, safety and tolerability of BI 1291583 qd over at least 24 weeks in patients with bronchiectasis (Airleaf*)

The primary objective of the trial is to assess a non-flat dose-response curve and to evaluate the dose-response relationship for 3 oral dose regimens of BI 1291583 versus placebo, on the primary endpoint, time to first pulmonary exacerbation up to…

Catalyst Trial: Clinical trial of atrial fibrillation patients comparing left atrial appendage occlusion therapy to non-vitamin K antagonist oral anticoagulants

The objective of this trial is to evaluate the safety and effectiveness of the Amulet device compared to NOAC therapy in patients with non-valvular AF at increased risk for ischemic stroke and who are recommended for long-term NOAC therapy.