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Human intestinal ischemia and reperfusion

This study aims at (further) revealing the pathophysiology of intestinal IR in man, with a specific interest for the role of proteases and protease-activated receptor-2 (PAR-2), cellular and inflammatory changes, barrier function and intestinal…

Postoperative sublingual microvascular blood flow following esophagectomy and the effect of dobutamine

- Primary Objective: to investigate whether the administration of a small amount of dobutamine postoperatively is able to positively influence the sublingual microcirculation in patients who are undergoing esophagectomy.- Secondary Objective: to…

Stress ulcer prophylaxis with proton pump inhibitor (pantoprazole) in adult critically ill patients in the intensive care unit: A randomized, blinded, placebocontrolled trial

To assess the benefits and harms of SUP with PPI in adult, critically ill patients in the ICU.

Early markers of gastrointestinal ischemia

To evaluate the use of the early serum markers I-FABP, D-dimer, DAO and alpha-GSTin predicting CGI one by one.To evaluate the use of Citrulline to determine the bowel function in patients with CGI.

Endoscopic visible light spectroscopy: optimizing the accuracy of diagnosing chronic gastrointestinal ischemia with luminal feeding stimulation (VLS-Study)

- To determine the difference in baseline mucosal oxygen saturation measurements and after luminal feeding between patients diagnosed with CGI and healthy subjects. - To determine the difference in baseline mucosal oxygen saturation measurements…

Electrogastrography as potential diagnostic test in patients with gastric ischemia

To determine the difference in EGG patterns in a fasting state and after a test meal between healthy controls and patients suffering from splanchnic ischemia (both single and multiple vessel stenosis). We hypothesize that patients with splanchnic…

Mucosal saturation measurements in patients suspected for chronic gastrointestinal ischemia

Evaluation of the diagnostic value of stomach and small bowel mucosal oxygen saturation measurements in patients suspected for chronic gastrointestinal ischemia.Determination of normal mucosal oxygen saturation values in patients without chronic…

Haemorrhoidal Artery Ligation Study: the surplus value of the Doppler

The objective is that 6 standard ligation of hemorrhoidal arteries is as effective as doppler guided.

Covered Stents versus Bare-Metal Stents in Chronic Atherosclerotic Gastrointestinal Ischemia

To compare the outcome of revascularisation the gastrointestinal arteries using covered stents compared to bare-metal stents in patients with CGI.

Labelled-butyrate and labelled-glucose breath testing to detect mesenteric ischemia, a proof of principle study in healthy volunteers

To explore the possibility of detecting mesenteric ischemia by 13C-butyrate, 13C-glucose, and 13C-glucose and D-butyrate breath testing by comparing the timing and concentration of the peak of expired 13CO2 and DHO.

Effectiveness of Somatostatin Analogues in Patients with hereditary hemorrhagic telangiectasia and symptomatic gastrointestinal bleeding, the SAIPAN-trial: a multicenter, randomized, open-label, parallelgroup, superiority trial.

To determine if SSA are effective in decreasing transfusion requirements and improving quality of life while being cost-effective.

The detrimental course of acute intestinal ischemia: improvement of the diagnosis

We aim to validate a panel of plasma biomarkers and investigate volatile biomarkers that potentially allow early and accurate identification of acute intestinal ischemia in patients. Second, we aim to identify a volatile organic compound (VOC)…