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Bone mineral density and muscle mass after risk-reducing salpingo-oophorectomy

We expect to find decreased bone mineral density compared to women of the same age in the general population and subclinical sarcopenia

Life Balance Study

A personalized, individual face-to-face program ’Managing Fatigue’ is effective to improve participation in people with FSHD or MM who experience chronic fatigue.

Mechanistische studie;
Glycocalyx measurements in premature atherosclerosis.

Glycocalyx volume is diminished in subjects with premature atherosclerosis.

Pre-endoscopic identification of patients at risk for inadequate bowel preparation to reduce the need for repeat colonoscopy procedures: external validation of a prediction model (PAYBACK-score)

We hypothesize that the prediction score can discriminate between low-risk and high-risk patients with moderate-good accuracy.

Efficacy and Safety Evaluation of Splendor-X SMART System for hair removal

We assume that hair removal treatment with the Splendor-X SMART is feasible.

Sickle Cell Outcome Research

More optimal prediction of SCD disease severity will lead to more precise management and treatment and development of novel therapeutic options.

The effect of IGF-I bioactivity on functional outcome after acute ischemic stroke.

We aim to compare IGF-I bioactivity levels between patients with favorable and unfavorable functional outcome 3 months after acute ischemic stroke. Furthermore, we will compare the IGF-I bioactivity levels between patients with and without…

(Cost)Effectiveness of the CPA Talking-with-children-intervention.

We hypothesize that the CPA Talking-with-children-intervention will have a beneficial effect on the mental health and quality of life of maltreated children. We expect that children who participate in the CPA investigation (CPA Talking-with-…

Generation of circulating tumor cell derived organoids
through enrichment by leukapheresis - A novel drug screening system in metastatic prostate cancer

We hypothesize that it is possible to culture circulating tumor cells obtained by leukapheresis into organoids.

Effectiveness Study of Electrical Stimulation in Prevention of Decubitus.

There have been several studies that showed a possible positive effect of electrical stimulation on wound healing. One of the working principles is increasing blood flow. This could mean that by giving frequent electrical stimulation on the foot and…

Intestinal Fatty Acid Binding Protein as a Marker for Increased Intra-Abdominal Pressure (I-Fabulous study)

It is expected that the urinary and serum level of intestinal fatty acid binding protein (I-FABP) and the urinary level of Claudin-3 have prognostic relevance for early identification of patients at risk for intestinal ischemia-related morbidity or…

Growing up after surgery for Congenital Diaphragmatic Hernia (CDH): Problems for life? A study to evaluate optimal medical and psychosocial care in CDH Follow-Up till adulthood (CDH-FU)

to improve the medical care on long term follow up

Observational cohort of patients treated with stereotactic radiotherapy for Oligo LYMPh nOde and other soft tissue metastasiS; the OLYMPOS cohort

The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…

Mr

To evaluate the incidence, risk factors and perinatal morbidity and mortality due to CA after TTTS treated with fetoscopic laser surgery

Prospective observational risk-analysis of the incidence and severity of pressure ulcers and wound infections in obese patients in the ICU.

Patients with a BMI > 30 kg/m2 in the ICU have a higher incidence of pressure ulcers and wound infections in the ICU compared with patients with a BMI 18-25kg/m2. They develop them sooner during admittance and the severity and time to…

Evaluation of most adequate pain medication in uterine artery embolisation for fibroma: PCA versus Epidural Analgesia.

Epidural Analgesia shows promising results in other procedures and is therefore thought to be effective in embolization of uterine leiomyomata as well.

Prospective Multicenter Microbiota Study for Evaluation and Monitoring of Severe Acute Pancreatitis

Gut dysbiosis drives disease processes driving morbidity and mortality in acute pancreatitis, such as infected pancreatic necrosis, and (persistent) multiple organ failure. A decrease in commensal members of the bacterial microbiome allows for…

Ik beweeg: Experiment 2.

An online motivational interviewing intervention which includes a virtual coach results into the higher levels of participation, evaluation and higher effects on intrinsic motivation, commitment and physical activity behaviour, compared to online…

Repeated IPC
ischemic preconditioning, RIPC, ischemic reperfusion injury, endothelial function, end-stage renal disease, flow-mediated dilation (FMD)

ischemisch preconditioneren (IPC), herhaalde IPC, ischemisch reperfusie schade, endotheel functie, flow-gemedieerde dilatatie

In this explorative study we will examine the impact of daily ischemic preconditioning on brachial artery endothelial function (measured as FMD%, before and after IRI) during 7 days in the non-shunt arm and lower limb in patients with end-stage…

DVT patiënts with positive PNH.

Prevalence of PNH in selection of patients with DVT. Patients younger than 30 years of age. patients with DVT on unusual places.