615 results
The primary objective is investigating the effectiveness of *Mindlight* in treating (sub)clinical symptoms of anxiety in children who are diagnosed with an autism spectrum disorder. The secondary objective is to examine the factors that moderate and…
Primary objective:Investigate the efficacy and safety of Vernakalant in the acute conversion of AF, as compared to Amiodarone and rate control alone, in critically ill patients admitted to the medical and non-cardiac surgical ICU.Secondary objective…
PRIMARY OBJECTIVESthe assessment if survival in grade III glioma without combined 1p/19q loss is improved by - daily temozolomide chemotherapy during radiotherapy - the administration of temozolomide after the end of radiotherapy SECONDARY…
There is still no level I-II evidence for cytoreductive surgery in recurrent ovarian cancer. This is also the conclusion of a Cochrane Review of Galaal et al. published in June 2010. The most active chemotherapy in platinum sensitive recurrent…
Our primary objective is to evaluate the effect of perioperative enteral and parenteral nutrition on amino acid profile and cardiomyocytes functioning in the cardiac surgical patient. Our secondary objective is to study the effect of the (par)…
Primary- To evaluate the initial and long-term clinical results in terms of function, quality of life and pain/satisfaction of the Signature* procedure compared to the standard operation instruments.- To evaluate the alignment of the Signature*…
To determine the effect of lithium treatment (plasma levels between 0,4-0,8 mEq/liter) versus placebo - in addition to riluzole 2dd 50 mg - on reaching a clinical endpoint in patients with ALS.
The primary objective of this study is to investigate whether pregabalin at a dose of 150-600 mg twice a day reduces pain in patients with chronic neuropathic pain after herniorraphy. This research question will be answered by testing of the…
This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…
The primary goal is to investigate if CBT plus ABF has an additional reducing effect on experienced fatigue and an additional positive effect on physical functioning, in comparison to CBT alone. Secondary goals are to investigate if CBT plus ABF has…
Which of two strategies for early detection of depression in primary care performs best, i.e. results in higher number of identified depressions. The two strategies are:1. Active case finding of high risk patients by a nurse practitioner;2. Routing…
Prolonged antibiotic treatment of patients diagnosed with presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term treatment as endorsed by the Dutch CBO guidelines.
Intraoperative verification of paranasal sinus malignancy resection with cone-beam computed tomography will lead to a higher rate of radical resection
Pre-operative comprehensive digital Cardiac Counseling (prehabilitation) will reduce the cumalative incidence of MACE at 1 year postoperatively in patients operated for a cardiovascular procedure.
Based on current literature we hypothesize that mindfulness based stress reduction training reduces psychological distress and improves 'positive mental health' in medical interns. Possibly MBSR can prevent psychological distress in the…
We hypothesize that dietary supplementation with seaweed will improve glucose regulation in T2DM patients.
Primary:- To evaluate the efficacy of Oxabact® following 52 weeks treatment in patients with maintained kidney function but below the lower limit of the normal range (eGFR < 90 ml/min/1.73 m2) and a total plasma oxalate concentration >…
Primary Objective: To compare the efficacy of MEDI-551 versus placebo in reducing the risk of an NMO/NMOSD attack in subjects with NMO/NMOSD.Secondary Objectives:1. To compare the efficacy of MEDI-551 versus placebo on the reduction of EDSS…
The purpose of this study is to determine the safety profile, the maximum tolerated dose (MTD) and the associated dose-limiting toxicities (DLTs) of S 81694 in combination with paclitaxel in mBC patients, and to investigate the antitumour activity…
To investigate the safety, tolerability and efficacy of STR-324 infusions in healthy subjects.Primary objective (Parts 1 and 2)* To assess and characterise the safety and the tolerability of STR-324, over a 4-hour (Part 1) and a 48-h infusion (Part…