17 results
We aim to identify immunological parameters during (immune)therapy. We will study the effect of (immune)therapy on generic immune mediators and more specifically for NK cell, T effector and Treg cell functionality. Furthermore, we will explore DNX…
This study has several objectives, in different (subsequent) study phases:• A1. Optimize and validate the technology of the VD to reach non-inferiority• B1. Demonstrate non-inferior performance and safety of the VD, for CE marking• B2. Demonstrate…
To assess the pharmacokinetics of various cytotoxic agents (carboplatin, cisplatin, cytarabine, dactinomycin, daunorubicin, dinutuximab bèta, doxorubicin, etoposide, methotrexate, vincristine or thiotepa) and kinase inhibitors (ALK, RAS pathway,…
The aim of this proof-of-concept study is to analyze the use of heart rate based variables using the Apple Watch:A) To predict Acute Chest Syndrome in patients hospitalized patients for painful crises;B) To predict painful crises in ambulant…
The purpose of this study is to evaluate the feasibility and efficiency of transducing freshly obtained CD34+ HSC from either mobilized peripheral blood or bone marrow of healthy donors using lentiviral SIN vectors encoding codon-optimized human…
The primary objective of this study is to investigate the effect of dried chicory root (WholeFiber) during 6 weeks on fecal SCFA levels in intermediate to high-risk melanoma patients after surgical treatment with no concurrent adjuvant treatment.…
Primary Objectives• To evaluate prognostic factors of disease progression in subjects with Stargardt disease secondary to mutation in the ABCA4 gene • To further characterize the STGD1 patient population for future interventional clinical studies
The aim of this study is to develop a Dutch adaptation and translation of the User Satisfaction Evaluation Questionnaire (USEQ), for measuring user satisfaction and usability in a Dutch pediatric population (6-18 years old), and to determine its…
MAIN GOAL: We will integrate population-level registry (CBS) data and data from a survey on beliefs, values, and behavior to build a model to predict SARS-CoV-2 vaccination uptake on a population and local level. This model will take into account…
This study has two objectives. First, to evaluate the measurement properties (construct validity, internal consistency, and responsiveness) of five different PROMs in the ED. These PROMs include the Quality of Recovery (QoR-15) scale, the Brief…
To assess the association between time-in-range blood pressure measurements and the risk of developing preeclampsia in women with hypertensive disorders of pregnancy. To evaluate the relationship between time-in-range blood pressure and gestational…
The objective is to investigate if AHCL in children with DM1 leads to a greater difference in BMI SDS compared to MDI. The second objective is to study if there is a difference between MDI and AHCL in DM1 regarding blood glucose regulation and…
The primary objective of this research is to assess the occurrence, variability and underlying causes of treating pediatric patients with respiratory infections at the ED. This is done in order to identify and ultimately de-implement ineffective…
The aim of this study is to investigate the association between adolescent-perceived parenting dimensions and vaping behaviour. It also aims to explore whether perceived stress mediates this relationship. The results may contribute to more…
Objective: To identify and characterize WD patients in the Netherlands. Secondary objectives of this study are; describe disease management and treatment patterns, examine treatment adherence and efficacy of current treatment options, gain insight…
The objective of this study is to create a more robust OR schedule for the operational level using artificial intelligence and operations research techniques. The objective is split into four sub-projects. Each sub project will look at an aspect of…