22 results
Identification of the dynamics of hs-cTnI and hs-TnT release during and after anthracycline treatment (doxorubicine in combination with cyclofosfamide) in breast cancer patients in order to determine the optimal sampling time point, most reflective…
The aim of this proof-of-concept study is to analyze the use of heart rate based variables using the Apple Watch:A) To predict Acute Chest Syndrome in patients hospitalized patients for painful crises;B) To predict painful crises in ambulant…
To investigate in healthy individuals not having ELP whether DUS and dynamic MRI may reveal a compressed popliteal artery in rest and during provocative testing (pointing, plantar foot flexion).
The primary objective of this study is to evaluate the diagnostic accuracy of physical examination and ultrasound to identify active synovial proliferation in haemophilia patients with subclinical synovial proliferation. The secondary…
The study will help us to determine 1. the necessary type of (combined) examinations and 2. the sample size that is essential to evaluate (future) genetic therapy in Usher syndrome type 2 and USH2A associated nsRP.
Primary Objective: Assess which digital health metrics are relevant to monitor for patients with (or highly suspected of having) obstructive sleep apnea before and after diagnosis, and during titration of treatment with continuous positive airway…
1. To identify the perceived barriers and facilitators for initiating and maintaining a healthy lifestyle in people with both DM2 and a low SEP. 2. To co-create a digital, personalised CBT lifestyle tool together with end users (people with DM2) to…
The purpose of this clinical study is to evaluate the safety and clinical efficacy of the VDyne System in the treatment of moderate or greater TR.
To generate a large, international Friedreich*s ataxia patient database (including healthy controls), alongside an integrated clinical and natural history database, which is linked to a biological samples and imaging repository, hereby creating a…
The purpose of this protocol amendment is to meet the current and future needs of the MacTel Project’s collaborating investigators and continue meeting initial objectives. In addition, a third objective is to understand the mechanisms involved in…
In this explorative study, we aim to: Analyze neoantigens expressed on different tumors of CMMRD patients, to identify more possible target antigens for DC vaccination studies and to select the antigens that are most frequent. …
Generation R studies growth, development and health from early pregnancy into adulthood. The study aims to contribute to the development of strategies for optimising health and health care across the full life course.
Generation R Next aims to examine the influence of preconception and pregnancy factors on growth, development and health of children from the earliest phase of life into young adulthood. The study aims to contribute to the development of strategies…
Whole genome comparison between microorganisms cultured from PJI and those cultured from preoperative swabs of the patients’ microbiome, to determine the origin of the infection.
To assess inter-individual and intra-individual variation in objective skin pigmentation measurement using non-invasive colorimetry and multispectral imaging in healthy individuals and patients with skin disease.
The aim of this study is to evaluate the relation between the effectiveness of endometriosis treatment and pelvic floor muscle function measured by direct functional measurements (functional ultrasound (strain) and EMG). Secondary objectives…
The main aim of this study is to investigate how brain water oscillations measured with NIRS correlate to blood pressure.
We aim to develop a library of different measurement protocols and data processing workflows that make it possible to measure biomechanics in the knee joint in individuals across the full spectrum of OA-related features from no OA through to severe…
The main objective of this study is to validate the specificity of 100% for peripheral thrombocytopenia of an IPF cut-off value of 13% in our patient population and workflow. In addition, if the specificity of 100% cannot be validated at a cut-off…
Objective: To identify and characterize WD patients in the Netherlands. Secondary objectives of this study are; describe disease management and treatment patterns, examine treatment adherence and efficacy of current treatment options, gain insight…