345 results
The primary objective of this study is to investigate the effect of food on the pharmacokinetics(PK) of olaparib following oral dosing of the tablet formulation in patients with advancedsolid tumours.The secondary objectives are to investigate the…
The aim is to critically evaluate the additive effect of EMDR to ERP on treatment acceptability, drop-out, and outcome; a) does EMDR lead to a decrease in OCD related memory representations (or in other words; does it lead to a decrease in the…
Primary objective of the study is to record TIP inhalations on video at home to study the association between inhalation manoeuver and cough. Secondary objectives are: To study the inhalation maneuvers of patients using TIP in the home situation; to…
We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).
The main purpose of this study is to find out whether EMDR is a safe and effective treatment to reduce the symptoms of PTSD in people with mild intellectual disability and borderline intellectual functioning. In addition, it is expected to reduce…
The aim of this project is to evaluate the clinical value of biomarkers in adult patients with pulmonary hypertension, in particular:1) To quantify biomarkers of neurohormonal activity as NTproBNP, endotheline-1 and of immunological activity as CRP…
Gaining insight in the modulating effects of attention on the processing of short electrocutaneous painful and non-painful stimuli by comparing the patterns in brain activity en subjective measurements during different conditions of attention.…
Primary objective: The main research issue here is whether the intervention with the mirrorfeedback in patients with motor conversion of the arm or hand leads to improvement handgrip strength.Secondary objectives: The secondary research question is…
(1) Investigate diagnostic performance (sensitivity) of HD bronchoscopy, with or without surface enhancement or tone enhancement in comparison to standard WLB for detecting abnormalities of the tracheobronchial tree. Furthermore we aim to…
To investigate inter-examiner variability of the alternate prism and cover test (APCT) measurements of ocular deviation at near and distance fixation, and to compare variability between adults/teenagers and children.
The main objectives of the present study are: determining short and long term effects of TF-CBT and EMDR; assessing the efficiency of these therapies; and identifying the characteristics of those children who do not respond to the given treatment.
2.1 Primary Objectives: 1) To test the feasibility of the six minute assisted leg and arm cycling test in patients aged 6-18 years with Duchenne muscular dystrophy (DMD), Beckers muscular dystrophy (BMD), Limb Girdle muscular dystrophy (LGMD),…
To evaluate the long-term safety and efficacy of BMN 110 administration at 2.0 mg/kg/qw and 2.0 mg/kg/qow in patients with MPS IVA.
The objective of the current study is to investigate the effect of mindfulness training on attention shifting in a pain setting. This question will be tested in an experimental design. Outcomes of the study will be used to further investigate…
Aim of this study is to investigate the clinical performance of two restoration techniques, making use of 'direct' and an 'indirect' composite restorations as a minimal invasive intervention in patients with severe tooth wear.…
To investigate the efficacy of cognitive behaviour therapy (CBT) on reducing TTF in patients receiving TKIs for CML or GIST.
Primary objectives:The primary objectives of this trial are:• To show PK similarity of BI 695500 to MabThera® and Rituxan® and of Rituxan® to MabThera® (three-way PK similarity).• To establish statistical equivalence of efficacy of BI 695500 and…
Objective: Bread aroma may increase consumer*s motivation to buy bread. Motivation for products is hard to measure reliably in real life settings like a supermarket, but can be studied via brain imaging. In this project, brain imaging is used to…
The main objective of this study is to assess the effect of visual cues (provided by smart glasses) in the form of visual lines on the floor on walking performance and occurrence of FOG in comparison to walking without visual cues and walking with…
The main objective is to investigate the preparatory process in left primary motor cortex in relation to hand choice during whole-body motion.